Polymorphism of the NIPAL1 gene rs135173498 as a marker of embryonic lethality in auliekol cattle

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Resumo

It was found that in Auliekol cattle, SNP G/A rs135173498 associated with live weight at birth (p-value = 2.71E-06) is characterized by the absence of live-born calves homozygous for the rare genotype with a significant sample size of 497 animals. At the same time, calves with a heterozygous genotype were not characterized by a decrease in live weight at birth relative to the values of this indicator for the sample as a whole. The article analyzes possible mechanisms for the development of the phenotypic effect of SNP rs135173498 of the NIPAL1 gene as a factor of embryonic lethality in Auliekol cattle, and, presumably, in the Kazakh Whitehead, Aberdeen Angus and Charolais breeds.

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Sobre autores

A. Belaya

Belarusian State Pedagogical University named after Maxim Tank

Autor responsável pela correspondência
Email: Kolyuchka005@rambler.ru
Belarus, Minsk

Е. Klimanova

Novosibirsk State Agrarian University

Email: Kolyuchka005@rambler.ru
Rússia, Novosibirsk

V. Norkina

Novosibirsk State Agrarian University

Email: Kolyuchka005@rambler.ru
Rússia, Novosibirsk

I. Beishova

Zhangir Khan West Kazakhstan Agrarian Technical University

Email: Kolyuchka005@rambler.ru
Cazaquistão, Uralsk

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2. Fig. 1. Quantile-quantile graphs (QQ plot). On the Y-axis are the observed values of p (converted using the inverse decimal logarithm of p, [15]).

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3. 2. Intracellular localization of NIPAL1 (GeneCards). The confidence scale is color-coded: from light green (1) for low confidence to dark green (5) for high confidence; white (0) indicates no signs of localization.

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4. Fig. 3. Protein–protein interactions of the protein product of the NIPAL1 gene, constructed using string-db.org (in cattle).

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5. 4. The level of NIPAL1 expression in 20 different human tissues (cited in [20]).

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