Synthesis of 3-Alkyl-5-(diethylaminomethyl)-1-(1,3-thiazole)pyrazoles

A. R. Karayeva; Караева А. Р.; M. I. Shatirova; Шатирова М. И.; B. A. Mamedov; Мамедов Б. А.; Sh. F. Nagieva; Нагиева Ш. Ф.; L. I. Gadzhiyeva; Гаджиева Л. Я.

doi:10.31857/S0514749224010091

Synthesis of 3-Alkyl-5-(diethylaminomethyl)-1-(1,3-thiazole)pyrazoles

Authors: Karayeva A.R.¹, Shatirova M.I.¹, Mamedov B.A.¹, Nagieva S.F.¹, Gadzhiyeva L.I.¹
Affiliations:
1. Institute of Polymer Materials of Ministry of Science and Education of Republic of Azerbaijan
Issue: Vol 60, No 1 (2024)
Pages: 104-108
Section: Articles
URL: https://ruspoj.com/0514-7492/article/view/672246
DOI: https://doi.org/10.31857/S0514749224010091
EDN: https://elibrary.ru/EMXWFD
ID: 672246

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Abstract

By the reaction of 3-alkyl-5-(diethylaminomethyl) pyrazoles with chloroanhydride of monochloroacetic acid, the pyrazoles with chloromethyl carbonyl substituent have been synthesized. Due to presence of reactive COCH₂Cl groups in a molecule, the pyrazoles have been subjected to heterocyclization with thicarbamides (thiobenzamide, thicarbamide and phenylthiocarbamide) in the presence of triethyleamine in a medium of ethanol, as a result of which the previously unknown 3-alkyl-5-diethylaminomethyl-1-(1,3-thiazol)substituted pyrazole derivatives have been obtained.

Keywords

pyrazoles, thiocarbamides, thiazoles, heterocyclization, pharmacophore groups

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