Disturbances of the process of synaptic elimination and its reflection in the wave N170 of auditory evoked potential (AEP) in first psychotic episode of paranoid schizophrenia

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Abstract

The reaction of cortical structures of different significance (associated with delusions and hallucination and neutral ones) was studied. The work was conducted in patients with paranoid schizophrenia and normal control (24 patients with paranoid schizophrenia, 15 controls). In patients in frontal areas paradox effect (PE) in AEPs with the increase of both parameters of N170 component was revealed. In central and temporal areas PEs were found in N170 component with the decrease of both parameters of this component. These results point to the “conflict” between the processes of excitation and inhibition in schizophrenia. In schizophrenia patients Pes were revealed in auditory and visual modalities (EVPs and VEPs) on the N170 wave with the unidirectional shifts (increase and decrease) of both parameters in the same cortical areas in AEPs and VEPs. It is supposed that ERP disturbances revealed in patients with schizophrenia are due to the pathology of the synaptic pruning causing the imbalance of excitation-inhibition and leading to the psychosis onset.

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About the authors

А. Yu. Arkhipov

Institute of Higher Nervous Activity and Neurophysiology of RAS

Email: sooperego@ya.ru
Russian Federation, Moscow

G. I. Rodionov

Institute of Higher Nervous Activity and Neurophysiology of RAS

Author for correspondence.
Email: sooperego@ya.ru
Russian Federation, Moscow

V. В. Strelets

Institute of Higher Nervous Activity and Neurophysiology of RAS

Email: sooperego@ya.ru
Russian Federation, Moscow

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2. Fig. 1. Activation of the cortex to an emotionally significant stimulus in healthy subjects compared to schizophrenia patients in the frontocentral region along the midline. The EP of healthy subjects is shown by the gray line, the EP of patients with paranoid schizophrenia is shown in black.

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3. Fig. 2. Cortical activation to an emotionally significant stimulus compared to a neutral one in healthy subjects in the right central-parietal region. The EP to the neutral stimulus is shown by the gray line, the EP to the emotionally significant stimulus is shown by the black line.

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4. Fig. 3. EP with a simultaneous increase in the latency and amplitude of the N170 wave in the central frontal region along the midline in patients with schizophrenia. EP to a neutral stimulus is shown by a gray line, EP to an emotionally significant stimulus – by a black line.

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5. Fig. 4. EP with a simultaneous decrease in the latency and amplitude of the N170 wave in the left central region in patients with schizophrenia. EP to a neutral stimulus is shown by a gray line, EP to an emotionally significant stimulus – by a black line.

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