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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Pediatric Ophthalmology</journal-id><journal-title-group><journal-title xml:lang="en">Russian Pediatric Ophthalmology</journal-title><trans-title-group xml:lang="ru"><trans-title>Российская педиатрическая офтальмология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1993-1859</issn><issn publication-format="electronic">2412-432X</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">37460</article-id><article-id pub-id-type="doi">10.17816/rpoj37460</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">PATHOMORPHISM IN MEIBOMIAN GLANDS UNDER PHYSIOTHERAPEUTIC FACTOR AND SOME MEDICATIONS IMPACT UNDER THE EXPERIMENTAL HYPOOESTROGENIA CONDITIONS</article-title><trans-title-group xml:lang="ru"><trans-title>Патоморфоз в мейбомиевых железах при воздействии физиотерапевтическим фактором и некоторыми лекарственными препаратами в условиях экспериментальной гипоэстрогении</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Obrubov</surname><given-names>S A</given-names></name><name xml:lang="ru"><surname>Обрубов</surname><given-names>Сергей Анатольевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф. каф. офтальмологии педиатрического фак; РГМУ</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Stavitskaya</surname><given-names>G V</given-names></name><name xml:lang="ru"><surname>Ставицкая</surname><given-names>Г В</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. биол. наук, доц. каф. морфологии медико-биологического фак; РГМУ</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dreval</surname><given-names>A A</given-names></name><name xml:lang="ru"><surname>Древаль</surname><given-names>А А</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. биол. наук, доц. каф. гистологии лечебного факультета; РГМУ</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Obrubov</surname><given-names>A S</given-names></name><name xml:lang="ru"><surname>Обрубов</surname><given-names>А С</given-names></name></name-alternatives><bio xml:lang="ru"><p>клин. ординатор каф. офтальмологии фак. усовершенствования врачей; РГМУ</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Obrubova</surname><given-names>G A</given-names></name><name xml:lang="ru"><surname>Обрубова</surname><given-names>Г А</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, врач акушер-гинеколог; Перинатальный медицинский центр Москвы</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Boginskaya</surname><given-names>O A</given-names></name><name xml:lang="ru"><surname>Богинская</surname><given-names>О А</given-names></name></name-alternatives><bio xml:lang="ru"><p>клин. ординатор каф. офтальмологии педиатрического фак; РГМУ</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">РГМУ</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Перинатальный медицинский  центр  Москвы</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2010-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2010</year></pub-date><volume>5</volume><issue>2</issue><issue-title xml:lang="en">NO2 (2010)</issue-title><issue-title xml:lang="ru">№2 (2010)</issue-title><fpage>38</fpage><lpage>41</lpage><history><date date-type="received" iso-8601-date="2020-07-21"><day>21</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2010, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2010, ООО "Эко-Вектор"</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://ruspoj.com/1993-1859/article/view/37460">https://ruspoj.com/1993-1859/article/view/37460</self-uri><abstract xml:lang="en"><p>Pathomorphism in meibomian glands in physiotherapeutic factor and some medications impact under experimental hypooestrogenia conditions was studied.
It was established that morphologic changes of meibomian glands have unidirectional character. The estrogenic medication Divigel is of most influence on the increase of the secretory follicles quantity and increase of the Malpighian layer of secretory follicles epithelium. The application of suis-organ preparation of estrogenic action (ovarium compositum) and impact by the pulse low-frequency electromagnetic field on the area of the animal's head has the most influence on the changes of microcirculatory bloodstream.</p></abstract><trans-abstract xml:lang="ru"><p>Изучен патоморфоз в мейбомиевых железах при воздействии физиотерапевтическим фактором и некоторыми лекарственными препаратами в условиях экспериментальной гипоэстрогении.
Установлено, что морфологические изменения мейбомиевых желез носят однонаправленный характер. Наибольшее влияние на увеличение количества секреторных фолликулов и увеличение росткового слоя эпителия секреторных фолликулов оказывает эстрогенный препарат дивигель. На изменения микроциркуляторного русла наибольшее влияние оказывает применение суис-органного препарата эстрогенной направленности (Овариум композитум) и воздействие импульсным низкочастотным электромагнитным полем на область головы животных.</p></trans-abstract><kwd-group xml:lang="en"><kwd>meibomian glands</kwd><kwd>morphologic structure</kwd><kwd>model of surgical castration of female rabbits</kwd><kwd>sex hormones</kwd><kwd>dry eye syndrome</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>мейбомиевые железы</kwd><kwd>морфологическая структура</kwd><kwd>модель хирургической кастрации крольчих</kwd><kwd>половые гормоны</kwd><kwd>синдром сухого глаза</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Бржевский В. В., Садовникова Н. Н. Значение половых стероидных гормонов в развитии синдрома "сухого глаза" // Сборник науч. трудов V Всероссийской школы офтальмолога. - М., 2006. - С. 442-449.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Akramian J., Wedrich A., Nepp J., Sator M. Estrogen therapy in keratoconjunctivitis sicca // Adv. Exp. Med. Biol. - 1998. - Vol. 438. - P. 1005-1009.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Gutgesell V. J., Stern G. A., Hood C. I. Histopathology of Meibomian gland dysfunction // Am. J. Ophthalmol. - 1982. - Vol. 94. - P. 393-387.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Mathers W. D. Meibomian gland disease // Dry Eye and Ocular Surface Disorders / Eds S. C. Pflugfelder et al. - New York; Basel, 2004. - P. 247-268.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Sator M. O., Golaszewsky T., Gruber D. Extragenital effects of hormone replacement therapy // IV European Congress on Menopause. - Viena, 1997. - P. 46.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Sator M. O., Joura E. A. Treatment of menopausal keratoconjunctivitis sicca with topical oestradiol // Br. J. Obstetr. Gynaecol. - 1998. - Vol. 105. - P. 100-102.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Schaumberg D. A., Buring J. E., Sullivan D. A., Dana M. R. Hormone replacement therapy and the prevalence of dry eye syndrome // J. A. M. A. - 2001. - Vol. 286. - P. 2114- 2119.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Sullivan D. A., Edwards J. A. Androgen stimaulation of lacrimal gland function in mouse models of Sjögren syndrome // J. Steroid Biochem. Mol. Biol. - 1997. - Vol. 60. - P. 237-245.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Sullivan D. A., Wickham L. A., Rocha E. M. et al. Influence of gender, sex steroid hormones and the hypothalamic-pituitary axic on the structure and function of the lacrimal gland // Adv. Exp. Med. Biol. - 1998. - Vol. 438. - P. 11-42.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Sullivan D. A., Krenzer K. L., Sullivan B. D. Does androgen insufficiency cause lacrimal gland inflammation and aqueous tear deficiency? // Invest. Ophthalmol. Vis. Sci. - 1999. - Vol. 40. - P. 1261-1265.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Sullivan D. A., Wickham L. A., Rochba E. M. Androgens and dry eye in Sjgren syndrome // Ann. N. Y. Acad. Sci. - 1999. - Vol. 876. - P. 312-324.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Sullivan D. A., Sullivan B. D., Ullman M. D. et al. Androgen influence on the Meibomian gland // Invest. Ophthalmol. Vis. Sci. - 2000. - Vol. 41, N 12. - P. 3732-3742.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Sullian B. D., Evans J. E., Cermak J. M. et al. Complete androgen insensivity syndrom // Arch. Ophthalmol. - 2002. - Vol. 120. - P. 1689-1699.</mixed-citation></ref></ref-list></back></article>
