Russian Pediatric OphthalmologyRussian Pediatric Ophthalmology1993-18592412-432XEco-Vector3755810.17816/rpoj37558Research ArticleSUPERSELECTIVE INTRA-ARTERIAL CHEMOTHERAPY FOR THE TREATMENT OF REFRACTORY AND ADVANCED RETINOBLASTOMA: POSSIBLE COMPLICATIONS AND MEASURES FOR THEIR PREVENTIONSaakyanS. V-ZharuaA. A-MyakoshinaE. Bmyakoshina@mail.ruLazarevaL. A-YakovlevS. B-Moscow Helmholtz Research Institute of Eye DiseasesN.N. Burdenko Research Institute of Neurosurgery1503201381313421072020Copyright © 2013, Eco-Vector2013The potential local and systemic complications of superselective intra-arterial chemotherapy used to treat refractory and advanced forms of retinoblastoma are considered in conjunction with the currently available measures of their prevention. In addition, possible causes of unsuccessful outcomes of this treatment modality are discussed.retinoblastomaintra-arterial chemotherapycomplicationsретинобластомаинтраартериальная химиотерапияосложнение[Бровкина А. Ф. Офтальмоонкология. - М., 2002.][Пантелеева О. Г. Ретинобластома: прогностическая значимость клинических симптомов, эффективность комбинированного лечения: Автореф. дис.. канд. мед. наук. -М., 1997.][Саакян С. В. Ранняя диагностика и лечение ретинобластомы: Дис. ... д-ра мед. наук. - М., 2002.][Саакян С. В. Ретинобластома. - М., 2005.][Abramson D. H., Dunkel I. J., Brodie S. E. et al. A phase I/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma initial results // Ophthalmology. - 2008. - Vol. 115. - P. 1398-1404.][Benz M. S., Scott I. U., Murray T. G. et al. Complications of systemic chemotherapy as treatment of retinoblastoma // Arch. Ophthalmol. - 2000. - Vol. 118. - P. 577-578.][Boutrid H., Wolfe S. Q., Murray T. G. et al. Bilateral orbital vasculature alterations after systemic chemotherapy and external beam radiation therapy treatment of advanced retinoblastoma: implications for intraarterial chemotherapy management // Retin. Cases Brief Rep. - 2010. - N 1. - P. 15.][Brodie S. E., Pierre Gobin Y. et al. Persistence of retinal function after selective ophthalmic artery chemotherapy infusion for retinoblastoma // Docum. Ophthalmol. - 2009. - Vol. 119. -N 1. - P. 13-22.][Dimaras H., Mallipatna A. C., Gallie B. L., Chan H. S. L. Chemotherapy focal therapy and beyond the importance of clinical trials & the role of retinoblastoma clinical studies conglomerate // XV-th Biannual Meeting International Society of Ocular Oncology. -Argentina, 2011. - Abstract Book. - P. 35.][Kaneko A., Mohri M. The technique of selective ophthalmicarterial infusion for conservative treatment of recurrent retinoblastoma [in Japanese] // Keio J. Med. - 1993. - Vol. 70. - P. 679-687.][Reese A. B., Hyman G., Tapley N., Forrest A. W. The treatment of retinoblastoma by x-ray and triethylene melamine // Arch. Ophthalmol. - 1958. - Vol. 60, N 5. - P. 897-906.][Shields J. A., Shields C. L. Management of retinoblastoma // Intraocular Tumors: An Atlas and Textbook / Eds. J. A. Shields, C. L. Shields. - 2nd Ed. - Philadelphia, 2008. - P. 333-352.][Shields C. L., Ramasubramanian A., Rosenwasser R., Shields J. A. Superselective catheterization of the ophthalmic artery for intraarterial chemotherapy for retinoblastoma // Retina. - 2009. - Vol. 29. - P. 1207-1209.][Shields C. L., Shields J. A. Intra-arterial chemotherapy for retinoblastoma: the beginning of a long journey // Clin. Exp. Ophthalmol. - 2010. - Vol. 38. - P. 638-643.][Vajzovic L. M., Murray T. G., Aziz-Sultan M. A. et al. Clinicopathologic review of enucleated eyes after intra-arterial chemotherapy with melphalan for advanced retinoblastoma // Arch. Ophthalmol. - 2010. - Vol. 128, N 12. - P. 1619-1623.][Yamane T., Kaneko A., Mohri M. The technique of ophthalmic arterial infusion therapy for patients with intraocular retinoblastoma // Int. J. Clin. Oncol. - 2004. - Vol. 9, N 2. - P. 69-73.]