Russian Pediatric OphthalmologyRussian Pediatric Ophthalmology1993-18592412-432XEco-Vector3760010.17816/rpoj37600Research ArticleClinical features of endocrine ophthalmopathy in childrenSaakyanS. V-PanteleevaOlga Gennadievnaolgpanteleeva@yandex.ruSirmaysO. S-The Helmholtz Moscow Research Institute of Eye Diseases1509201493202321072020Copyright © 2014, Eco-Vector2014This paper reports the frequency and prevalence of thyroid associated ophthalmopathy in children. 3031 patients with thyroid associated ophthalmopathy at the age from 3 to 78 years (mean - 44,2 ± 5,26), 0.8 % (24 people) of which were children at the age from 3 to 17 years. Complex conducted clinical and instrumental examination performed in accordance with EUGOGO. The children’s endocrinologist examination confirmed the diagnosis among children: often at diffuse toxic goiter - 19 people , autoimmune thyroiditis - 4 children , in one case - thyroid cancer. Unlike adult contingent, in no cases we observed severe cornea affection and IOP increasing. Active stage of thyroid associated ophthalmopathy was revealed in a quarter of children (6 patients). All patients with active stage thyroid associated ophthalmopathy were in puberty. In no cases we observed myogenic type of TAO and orbit apex syndrome. Children’s age mean 12,7 ± 3,28 years. Most often thyroid associated ophthalmopathy preceded by diffuse toxic goiter. The clinical symptoms of thyroid associated ophthalmopathy in children did not differ from adults. Clinical symptoms of thyroid associated ophthalmopathy did not differ among adults and children. In 11 from 12 children symptoms of the optic neuropathy were identified. In 17 children the mixed type of thyroid associated ophthalmopathy were diagnosed.thyroid associated ophthalmopathydiffuse toxic goitereye symptomsteenagerschildrenэндокринная офтальмопатиядиффузный токсический зобглазные симптомыподросткидети[Дефицит йода - угроза здоровью и развитию детей России: Национальный доклад / Дедов И.И., Мельниченко Г.А., Трошина Е.А., Платонова Н.М., Абдулхабирова Ф.М., Шатнюк Л.Н. и др. М.: 2006.][Perros P., Crombie A.L., Matthews J.N., Kendall-Taylor P. Age and gender influence the severity of thyroid-associated ophthalmopathy: a study of 101 patients attending a combined thyroid-eye clinic. Clin. Endocrinol. (Oxf.). 1993; 38: 367-72.][Kendall-Taylor P., Perros P. Clinical presentation of thyroid associated orbitopathy. Thyroid. 1998; 8: 427-8.][Касаткина Э.П., Петрова Л.М., Пермяков С.В. и др. Йодное обеспечение детского населения на юге Центрально-черноземного региона России. Проблемы эндокринологии. 1999; 45(1): 29-34.][Дедов И.И., Петеркова В.А. Руководство по детской эндокринологии. М.: Универсум Паблишинг; 2006.][Gogakos A.I., Boboridis K., Krassas G.E. Pediatric aspects in Grave’s orbitopathy. Pediatr. Endocrinol. Rev. 2010; Suppl. 2: 234-44.][Yalfin H., Akfora V., Balci A. Grave’s disease with exophtalmia in a two-year old child. Mol. Imag. Radionucl. Ther. 2011; 20(3): 11l-3.][Weetman A.P. Grave’s disease. N. Engl. J. Med. 2000; 343: 1236-48.][Nabhan Z.M., Kreher N.C., Eugster E.A. Hashitoxicosis in children: clinical features and natural history. J. Pediatr. 2005; 146: 533-6.][Clinical assessment of patients with Grave’s orbitopathy: the European Group on Grave’s Orbitopathy recommendations to generalists, specialists and clinical researchers. European Group on Grave’s Orbitopathy (EUGOGO). Eur. J. Endocriuol. 2006; 155(3): 387-9.][Krassas G.E. Childhood Grave’s disease and its ophthalmic complications: some sensitive issues. J. Endocrinol. Invest. 2008; 31(6): 582.][Wiersinga W.M. Thyroid associated ophthalmopathy: pediatric and endocrine aspects. Pediatr. Endocrinol. Rev. 2004; 1(Suppl. 3): 513-7.][Krassas G.E., Gogakos A. Thyroid-associated ophthalmopathy in juvenile Grave’s disease - clinical, endocrine and therapeutic aspects. J. Pediatr. Endocrinol. Metabol. 2006; 19: 1193-206.][Бровкина А.Ф., Гусев Г.А., Пантелеева О.Г. Оптическая нейропатия у больных отечным экзофтальмом. Русский медицинский журнал. Клиническая офтальмология. 2000; 1(2): 41-2.][Пантелеева О.Г Современная концепция механизма развития нарушений зрительных функций при эндокринной офтальмопатии: Дис.. д-ра мед. наук. М.; 2007.]