Russian Pediatric OphthalmologyRussian Pediatric Ophthalmology1993-18592412-432XEco-Vector3956810.18821/1993-1859-2017-12-3-163-165Research ArticleTHE CLINICAL CASES OF PALLISTER-KILLIANS’S SYNDROME IN A CHILDSudovskayaT. VThe Helmholtz Moscow Research Institute of Eye Diseases, Moscow, 105062, Russian Federationinfo@igb.ruKokoevaN. Sh-BobrovskayaYu. A-MakarovaA. A-The Helmholtz Moscow Research Institute of Eye Diseases, Russian Ministry of Health1509201712316316522072020Copyright © 2017, Eco-Vector2017This article was designed to report a clinical case of a rare syndromic disease - Pallister-Killians’s syndrome characterized by the signs of mental deficiency, abnormal features of cranial bones , congenitally reduced arterial pressure, multiple abnormalities of the facial features (including the eyes and the mouth cavity), ears, skeleton, the cardiovascular system, nervous system, and other systems of the body. The syndrome was described for the first time in 1977 by Philip Pallister and thereafter investigated in more detail by Maria Teschler-Nicola and Wolfgang Killian in 1981. In our case, the somatic status of a 3 month-old child presenting with this pathological condition was characterized by a large variety of congenital defects of the nervous system, including corpus collosum hypoxia, ischemic lesions of the brain tissue, bilateral subependymal pseudocysts, lenticulostriate agniopathies, and congenital heart failure. The pathological changes of the visual analyzer manifested themselves as unilateral grade 3 microphthalmos, sclerocornea, optic nerve disk coloboma, narrowing of the palpebral fissure, considerable decrease of the size of the conjunctival cavity in the absence of the appreciable alterations in the eye ball. Rehabilitation of the affected child with congenital microphthalmos included gradual ocular prosthetics and the treatment by the specialists of other medical professions.Pallister-Killian’s syndrome in childrencongenital microphthalmosrehabilitation of children with congenital microphthalmiasclerocorneaoptic nerve disk colobomarehabilitation of the children withсиндром Паллистера-Киллиана у детейврожденный микрофтальмсклерокорнеаколобома диска зрительного нервареабилитация детей с врожденным микрофтальмом[Шилова Н.В., Козлова Ю.О., Демина Н.А. и др. Синдром Паллистера-Киллиана: особенности пре- и постнатальной диагностики. Медицинская генетика. 2012; (3): 20-5.][Коровенков Р.И. Наследственные и врожденные заболевания глаз. СПб.: Химиздат; 2006.][Арефьев В.А., Лисовенко Л.А. Англо-русский толковый словарь генетических терминов. М.: Издательство ВНИРО; 1995.][Филатова И.А. Оптимальный подход к реабилитации пациентов с врожденным анофтальмом и микрофтальмом. Рос. педиатр. офтальмол. 2014; (2): 44-8.][Mourianus F., Audo I., Defoort-Dhellemmes S., Labalette P. et al. Management of congenital microftalmos and anophthalmos. J. Fr. Ophtalmol 1997; 20 (8): 583-91.][Rodallec A., Dufier J.L., Ernest C., Haye C. Congenital anophthalmos. Control of osteogenesis with an expanding intraorbital prosthesis. J. Fr. Ophtalmol. 1989; 11 (10): 661-8.]