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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Pediatric Ophthalmology</journal-id><journal-title-group><journal-title xml:lang="en">Russian Pediatric Ophthalmology</journal-title><trans-title-group xml:lang="ru"><trans-title>Российская педиатрическая офтальмология</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1993-1859</issn><issn publication-format="electronic">2412-432X</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">530661</article-id><article-id pub-id-type="doi">10.17816/rpoj530661</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original study article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Evaluation of retinal angioarchitectonics by optical coherence angiography and its diagnostic value in functional amblyopia</article-title><trans-title-group xml:lang="ru"><trans-title>Оценка ангиоархитектоники сетчатки методом оптической когерентной ангиографии и её диагностическая ценность при функциональной амблиопии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8383-0127</contrib-id><contrib-id contrib-id-type="spin">1032-8283</contrib-id><name-alternatives><name xml:lang="en"><surname>Stalmakhova</surname><given-names>Regina R.</given-names></name><name xml:lang="ru"><surname>Стальмахова</surname><given-names>Регина Расуловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>reginahubieva@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7669-1256</contrib-id><name-alternatives><name xml:lang="en"><surname>Apaev</surname><given-names>Alexander  V.</given-names></name><name xml:lang="ru"><surname>Апаев</surname><given-names>Александр Вячеславович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Researcher</p></bio><bio xml:lang="ru"><p>научный сотрудник</p></bio><email>doc229@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7621-4190</contrib-id><contrib-id contrib-id-type="spin">8715-0625</contrib-id><name-alternatives><name xml:lang="en"><surname>Larina</surname><given-names>Tatyana  Yu.</given-names></name><name xml:lang="ru"><surname>Ларина</surname><given-names>Татьяна Юрьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>tlpenguin@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Helmholtz National Medical Research Center of Eye Diseases</institution></aff><aff><institution xml:lang="ru">НМИЦ глазных болезней им. Гельмгольца</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-10-22" publication-format="electronic"><day>22</day><month>10</month><year>2023</year></pub-date><volume>18</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>137</fpage><lpage>144</lpage><history><date date-type="received" iso-8601-date="2023-07-06"><day>06</day><month>07</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-07-17"><day>17</day><month>07</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Эко-Вектор</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2025-10-22"/></permissions><self-uri xlink:href="https://ruspoj.com/1993-1859/article/view/530661">https://ruspoj.com/1993-1859/article/view/530661</self-uri><abstract xml:lang="en"><p><bold><italic>AIM</italic></bold><italic>: </italic>This study aimed to evaluate the density parameters of the superficial and deep plexuses of the retina, choriocapillary layer, and avascular zone in eyes with amblyopia of various origins and paired fellow eyes.</p> <p><bold><italic>MATERIAL AND METHODS</italic></bold><italic>: </italic>The study included 40 patients aged 6–16 (mean, 8.72±3.04) years. All patients were divided into 2 groups: group 1 included amblyopic, dysbinocular, and anisometropic eyes (n=48), and group 2 (control group) included paired fellow eyes without amblyopia (n=32). The density of the superficial and deep vascular plexuses of the retina, choriocapillary layer, and avascular zone parameters (area, perimeter, and circumference) were evaluated using spectral optical coherence tomography (RS-3000 Advance 2, Nidek, Japan). Correlation analysis was performed using Pearson’s linear correlation coefficient (r).</p> <p><bold><italic>RESULTS</italic></bold><italic>: </italic>No significant differences were found in the density of the superficial and deep retinal vessels, choriocapillary layer, and avascular zone parameters of the retina in eyes amblyopia of various origins compared with paired fellow eyes (<italic>p</italic> &gt;0.05). No correlation was found between retinal perfusion data and functional and anatomical parameters of amblyopic eyes.</p> <p><bold><italic>CONCLUSION</italic></bold><italic>: </italic>No relationship was noted between the vascular parameters of the posterior pole of the eye and the maximally corrected visual acuity, which confirms the absence of changes in retinal perfusion in amblyopia and excludes its role in the pathogenesis.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель</bold>. Изучить параметры плотности поверхностного и глубокого сплетений сетчатки, слоя хориокапилляров, параметров аваскулярной зоны сетчатки в глазах с амблиопией различного генеза и в парных здоровых глазах.</p> <p><bold>Материал и методы</bold>. В исследование были включены 40 пациентов в возрасте от 6 до 16 лет (в среднем 8,72±3,04 года). Все пациенты были разделены на две группы: 1-я группа — пациенты с дисбинокулярной и анизометропической амблиопией (48 глаз); 2-я группа — контрольная, парные здоровые глаза без амблиопии (32 глаза). Исследовали плотность поверхностного и глубокого сосудистых сплетений сетчатки, слоя хориокапилляров, параметры аваскулярной зоны (площадь, периметр, окружность) на спектральном оптическом когерентном томографе RS-3000 Advance 2 (Nidek, Japan). Корреляционный анализ проводился с использованием линейного коэффициента корреляции Пирсона (r).</p> <p><bold>Результаты</bold>. Не выявлено достоверных различий плотности поверхностных и глубоких сосудов сетчатки, слоя хорио-капилляров и параметров аваскулярной зоны сетчатки при амблиопии различного генеза по сравнению с парными здоровыми глазами. Не выявлено корреляционной взаимосвязи данных перфузии сетчатки с функциональными и анатомическими параметрами глаз с амблиопией.</p> <p><bold>Заключение</bold>. Не выявлено взаимосвязи сосудистых параметров заднего полюса глаза с максимально корригированной остротой зрения, что подтверждает отсутствие изменений в перфузии сетчатки при амблиопии и исключает её роль в патогенезе данного заболевания.</p></trans-abstract><kwd-group xml:lang="en"><kwd>аmblyopia</kwd><kwd>angiography</kwd><kwd>optical coherence tomography</kwd><kwd>retina</kwd><kwd>choriocapillaries</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>амблиопия</kwd><kwd>ангиография</kwd><kwd>оптическая когерентная томография</kwd><kwd>сетчатка</kwd><kwd>хориокапилляры</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Gerali PS, Flom MC, Raab EL. Report of the Children’s Vision Screening Task Force. Schaumburg, IL: National Society to Prevent Blindness; 1990.</mixed-citation><mixed-citation xml:lang="ru">Gerali P.S., Flom M.C., Raab E.L. 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