On the issue of the toxic effect of bromine and its inorganic compounds on the body (literature review)

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The study of the influence of various chemical elements on the human body is a relevant area, since it allows detecting the patterns of distribution and migration of these elements in tissues, as well as their role in the development of specific diseases. Among inorganic chemicals, a special place is occupied by bromine and its inorganic compounds widely used in industry, agriculture, and medicine. The search and selection of literature sources to identify the physiological effects and features of the toxic impact of bromine and bromide compounds on the human body and experimental animals was carried out using bibliographic databases: Scopus, MedLine, Web of Science, PubMed, The Cochrane Library, RISC, Cyberleninka. Data analysis showed bromine and hydrobromic acid to be classified as highly hazardous substances (hazard class 2), and calcium bromide and sodium bromide are considered moderately hazardous ones (hazard class 3). In high concentrations, all substances have an irritating effect. The most affected organs and systems are: central nervous system, respiratory system, gastrointestinal tract, liver, kidneys, thyroid gland, mucous membranes, skin, eyes. They cause a violation of metabolic processes, primarily mineral ones.

Contribution:
Gorohova L.G. – the concept of the study, collection of material, writing the text;
Mikhailova N.N. – editing.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: April 15, 2024 / Accepted: June 19, 2024 / Published: July 31, 2024

Sobre autores

Larisa Gorokhova

Research Institute for Complex Problems of Hygiene and Occupational Diseases; Kuzbass Humanitarian and Pedagogical Institute of the “Kemerovo State University”

Autor responsável pela correspondência
Email: ponomarikova@mail.ru
ORCID ID: 0000-0002-0545-631X

MD, PhD, leading researcher, Lab. of molecular genetics and experimental research of the Research Institute for Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation; Associate Professor of the Department natural science disciplines of the Kuzbass Humanitarian and Pedagogical Institute of the Kemerovo State University, Novokuznetsk, 654041, Russian Federation

e-mail: ponomarikova@mail.ru

Rússia

Nadezhda Mikhailova

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: napmih@mail.ru
ORCID ID: 0000-0002-1127-6980

MD, PhD, DSci., chief researcher, Lab. of molecular genetics and experimental research of the Research Institute for Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation

e-mail: napmih@mail.ru

Rússia

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