Accumulation of cadmium in organs of experimental animals and its effect on the content of essential elements in the chronic intoxication
- Authors: Fazlieva A.S.1, Karimov D.O.1, Daukaev R.A.1, Kurilov M.V.1, Ziatdinova M.M.1, Valova Y.V.1, Afonkina S.R.1, Zelenkovskaya E.E.1
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Affiliations:
- Ufa Research Institute of Occupational Health and Human Ecology
- Issue: Vol 100, No 11 (2021)
- Pages: 1303-1309
- Section: PREVENTIVE TOXICOLOGY AND HYGIENIC STANDARTIZATION
- Published: 06.12.2021
- URL: https://ruspoj.com/0016-9900/article/view/638802
- DOI: https://doi.org/10.47470/0016-9900-2021-100-11-1303-1309
- ID: 638802
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Abstract
Introduction. This article presents the results of studying the effects of cadmium chloride and its accumulation in experimental animals’ liver, kidneys, and blood. The impact of cadmium consumption on basic bioelements (zinc, copper, calcium) in organs was assessed.
Materials and methods. Experimental groups of white outbred rats were exposed daily for three months to a cadmium chloride solution containing 1, 10 and 100 μg of cadmium. Cadmium exposure was assessed at 1, 4, 12, 30, 60 and 90 days. The concentrations of cadmium, calcium, copper and zinc were measured by atomic absorption spectrometry.
Results. Whole blood cadmium concentration was not statistically different from the control group. The accumulation of cadmium in the blood was observed only after three months of exposure to a dose of 100 μg. The accumulation of cadmium in the liver occurred after one and two months of intoxication, depending on the dose. In the kidneys, an increase in cadmium occurred in all experimental groups after one month of injection. The metal content depended on the level of exposure, but no difference was observed between the liver and kidney. The concentration of zinc and calcium decreased in the kidneys and liver.
Conclusion. Changes in calcium and zinc, accompanied by elevated levels of cadmium in the liver and kidneys, suggest that cadmium may interfere with the biological processes in which these elements are involved.
Contribution:
Fazlieva A.S. — the concept and design of the study. collection and processing of material. statistical processing. writing a text;
Karimov D.O., Daukaev R.A. — the concept and design of the study, еditing;
Kurilov M.V., Ziatdinova M.M., Valova Y.V. — collection and processing of the material;
Afonkina S.R., Zelenkovskaya E.E. — collection of literature data.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.
The conclusion of the bioethical commission: the bioethical commission of the Ufa Research Institute of Occupational Medicine and Human Ecology (minutes of the BEC meeting dated June 10, 2021, No. 4-06) established that all types of research used in experimental work with animals were carried out in strict accordance with the legislation of the Russian Federation. Federation, the provisions of the “European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes”, requirements and recommendations of “Guidelines for laboratory animals and alternative models in biomedical technology.” Laboratory staff used humane and rational methods of keeping, handling animals and their use for scientific purposes and testing (research).
Conflict of interest. The authors declare no conflict of interest.
Acknowledgement. The study had no sponsorship.
Received: June 06, 2021 / Accepted: September 28, 2021 / Published: November 30, 2021
Keywords
About the authors
Anna S. Fazlieva
Ufa Research Institute of Occupational Health and Human Ecology
Author for correspondence.
Email: nytik-21@yandex.ru
ORCID iD: 0000-0002-0037-6791
MD, junior researcher of Ufa Research Institute of Occupational Health and Human Ecology, Ufa, 450106, Russian Federation.
e-mail: nytik-21@yandex.ru
Russian FederationDenis O. Karimov
Ufa Research Institute of Occupational Health and Human Ecology
Email: noemail@neicon.ru
ORCID iD: 0000-0003-0039-6757
Russian Federation
Rustem A. Daukaev
Ufa Research Institute of Occupational Health and Human Ecology
Email: noemail@neicon.ru
ORCID iD: 0000-0002-0421-4802
Russian Federation
Mihail V. Kurilov
Ufa Research Institute of Occupational Health and Human Ecology
Email: noemail@neicon.ru
ORCID iD: 0000-0002-2818-1558
Russian Federation
Munira M. Ziatdinova
Ufa Research Institute of Occupational Health and Human Ecology
Email: noemail@neicon.ru
ORCID iD: 0000-0002-1848-7959
Russian Federation
Yana V. Valova
Ufa Research Institute of Occupational Health and Human Ecology
Email: noemail@neicon.ru
ORCID iD: 0000-0001-6605-9994
Russian Federation
Svetlana R. Afonkina
Ufa Research Institute of Occupational Health and Human Ecology
Email: noemail@neicon.ru
ORCID iD: 0000-0003-0445-9057
Russian Federation
Evgeniya E. Zelenkovskaya
Ufa Research Institute of Occupational Health and Human Ecology
Email: noemail@neicon.ru
ORCID iD: 0000-0001-7682-2703
Russian Federation
References
- Gall J.E., Boyd R.S., Rajakaruna N. Transfer of heavy metals through terrestrial food webs: a review. Environ. Monit. Assess. 2015; 187(4): 1–21. https://doi.org/10.1007/s10661-015-4436-3
- Mann R.M., Vijver M.G., Peijnenburg W. Metals and metalloids in terrestrial systems: Bioaccumulation, biomagnification and subsequent adverse effects. In: Ecological Impacts of Toxic Chemicals. Bentham Science Publishers; 2011: 43–62.
- Efremova M., Izosimova A. Contamination of agricultural soils with heavy metals. Sustainable agriculture. 2012: 250–2.
- Jiao W., Chen W., Chang A.C., Page A.L. Environmental risks of trace elements associated with long-term phosphate fertilizers applications: a review. Environ. Pollution. 2012; 168: 44–53. https://doi.org/10.1016/j.envpol.2012.03.052
- Suwazono Y., Kido T., Nakagawa H., Nishijo M., Honda R., Kobayashi E., et al. Biological half-life of cadmium in the urine of inhabitants after cessation of cadmium exposure. Biomarkers. 2009; 14(2): 77–81. https://doi.org/10.1080/13547500902730698
- Ciobanu C., Slencu B.G., Cuciureanu R. Estimation of dietary intake of cadmium and lead through food consumption. Rev. Med. Chir. Soc. Med. Nat. Iasi. 2012; 116(2): 617–23.
- Zhang H., Reynolds M. Cadmium exposure in living organisms: A short review. Sci. Total Environ. 2019; 678: 761–7. https://doi.org/10.1016/j.scitotenv.2019.04.395
- Andjelkovic M., Buha Djordjevic A., Antonijevic E., Antonijevic B., Stanic M., Kotur-Stevuljevic J., et al. Toxic effect of acute cadmium and lead exposure in rat blood, liver and kidney. Int. J. Environ. Res. Public Health. 2019; 16(2): 274. https://doi.org/10.3390/ijerph16020274
- Egger A.E., Grabmann G., Gollmann-Tepeköylü C., Pechriggl E.J., Artner C., Türkcan A., et al. Chemical imaging and assessment of cadmium distribution in the human body. Metallomics. 2019; 11(12): 2010–9. https://doi.org/10.1039/c9mt00178f
- Khadartseva M.P., Brin V.B. Cadmium Nephropathy in Conditions of Altered Calcium Metabolism [Kadmievaya nefropatiya v usloviyakh izmenennogo obmena kal’tsiya]. Saarbryukken: LAP LAMBERT; 2012. (in Russian)
- Zhang T., Gao X., Luo X., Li L., Ma M., Zhu Y., et al. The effects of long-term exposure to low doses of cadmium on the health of the next generation of mice. Chem. Biol. Interact. 2019; 312: 108792. https://doi.org/10.1016/j.cbi.2019.108792
- Satarug S., Gobe G.C., Ujjin P., Vesey D.A. A comparison of the nephrotoxicity of low doses of cadmium and lead. Toxics. 2020; 8(1): 18. https://doi.org/10.3390/toxics8010018
- ATSDR’s Substance Priority List. Available at: https://wwwn.cdc.gov/TSP/ToxProfiles/ToxProfiles.aspx?id=48&tid=15
- Thijssen S., Maringwa J., Faes C., Lambrichts I., Kerkhove E.V. Chronic exposure of mice to environmentally relevant, low doses of cadmium leads to early renal damage, not predicted by blood or urine cadmium levels. Toxicology. 2007; 229(1–2): 145–56. https://doi.org/10.1016/j.tox.2006.10.011
- Lind Y., Engman J., Jorhem L., Glynn A.W. Cadmium accumulation in liver and kidney of mice exposed to the same weekly cadmium dose continuously or once a week. Food Chem. Toxicol. 1997; 35(9): 891–5. https://doi.org/10.1016/S0278-6915(97)00068-9
- Evcimen M., Aslan R., Gulay M.S. Protective effects of polydatin and grape seed extract in rats exposed to cadmium. Drug. Chem. Toxicol. 2020; 43(3): 225–33. https://doi.org/10.1080/01480545.2018.1480629
- Jurczuk M., Brzóska M., Moniuszko-Jakoniuk J., Gałażyn-Sidorczuk M., Kulikowska-Karpińska E. Antioxidant enzymes activity and lipid peroxidation in liver and kidney of rats exposed to cadmium and ethanol. Food Chem. Toxicol. 2004; 42(3): 429–38. https://doi.org/10.1016/j.fct.2003.10.005
- Winiarska-Mieczan A., Kwiecień M. The effect of exposure to cd and pb in the form of a drinking water or feed on the accumulation and distribution of these metals in the organs of growing wistar rats. Biol. Trace Elem. Res. 2016; 169(2): 230–6. https://doi.org/10.1007/s12011-015-0414-4
- Akhpolova V.O., Brin V.B. Actual concepts of heavy metals’ kinetics and pathogenesis of toxicity. Vestnik novykh meditsinskikh tekhnologiy. 2020; 27(1): 55–61. https://doi.org/10.24411/1609-2163-2020-16578 (in Russian)
- Richter P., Faroon O., Pappas R.S. Cadmium and cadmium/zinc ratios and tobacco-related morbidities. Int. J. Environ. Res. Public Health. 2017; 14(10): 1154. https://doi.org/10.3390/ijerph14101154
- Buzoeva M.R., Brin V.B. Melaxen influence on the functional state of the kidneys under conditions of cadmium intoxication on the background of hypercalcemia. Vestnik novykh meditsinskikh tekhnologiy. 2019; 26(3): 64–7. https://doi.org/10.24411/1609-2163-2019-16433 (in Russian)
- Brzóska M.M., Moniuszko-Jakoniuk J., Jurczuk M., Gałazyn-Sidorczuk M., Rogalska J. Effect of short-term ethanol administration on cadmium retention and bioelement metabolism in rats continuously exposed to cadmium. Alcohol. 2000; 35(5): 439–45. https://doi.org/10.1093/alcalc/35.5.439
- Kumar N., Kumari V., Ram C., Bharath Kumar B.S., Verma S. Impact of oral cadmium intoxication on levels of different essential trace elements and oxidative stress measures in mice: a response to dose. Environ. Sci. Pollut. Res. Int. 2018; 25(6): 5401–11. https://doi.org/10.1007/s11356-017-0868-3
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