Immune and genetic status of women with reproductive disorders in the condtions of exposed contamination of biological media with phenols

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Abstract

Introduction. A Hormon-like agent such as phenol is able both to integrate into the work of hypothalamus-pituitary-ovary system and trigger a cascade of responses that leads to the development of the immune, hormonal and endocrine systems disorder.

Material and methods. The study included 181 woman who permanently live in the area with contamination with phenol in air above standard level. All women are comparable in age, material status and ethnicity. Immunological and hormonal indices were determined by enzyme immunoassay, genetic markers were detected by polymerase chain reaction. Statistical data processing was carried out with the soffware Statistica 10.0, using parametric and non-parametric methods.

Results. Between the study groups there were obtained significant differences in following markers: thyroid-stimulating hormone, serotonin, interleukin 6, interleukin 10, estradiol. The dependence of appearance of unfavorable reproductive effects on the presence of polymorphic allele’s was determined: A allele of a gene SULT1A1, G allele of a gene PER2, C allele of a gene SIRT1.

Correlation models are defined: thyroid-stimulating hormone and phenol, serotonin and phenol, thyroid-stimulating hormone and cresol, serotonin and cresol, estradiol and cresol.

Conclusion. All found markers (increased concentration of phenol in biological media, gene polymorphism, altered protein and receptor expression) create special conditions for the course of the miscarriage pathology.

About the authors

O. A. Kazakova

Federal Research Center for Medical and Preventive Technologies of Public Health Risk Management

Author for correspondence.
Email: noemail@neicon.ru
ORCID iD: 0000-0002-0114-3930
Russian Federation

Oleg V. Dolgikh

Federal Research Center for Medical and Preventive Technologies of Public Health Risk Management; Perm state national research University; Perm National Research Polytechnic University

Email: oleg@fcrisk.ru
ORCID iD: 0000-0003-4860-3145

MD, Ph.D., DSci., Head of the Department immunological methods of diagnosis Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, 614045, Russian Federation.

e-mail: oleg@fcrisk.ru

Russian Federation

O. O. Sinitsyna

Institute of complex problems of hygiene F.F. Erisman Federal Scientific Center of Hygiene

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0241-0690
Russian Federation

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