Study of the state of reproductive health of women in the conditions of production exposure to acrylonitrile

At workplaces in the observation group, working conditions are characterized by a combined effect of the industrial noise and a chemical factor (at 13.4% of working places the class of working conditions is 3.1, at 63.3% of workplaces the class of working conditions is 3.2). In the comparison group, working conditions are characterized by the impact of electromagnetic radiation from a personal computer, the class of working conditions corresponds to an allowable 2^nd class. The executed research showed that under working conditions with an acrylonitrile concentration of 0.01 ± 0.003 mg/m³ (MPC of 0.5 mg/m³), working conditions do not provide safety for the reproductive health of female workers. An analysis of the results of the studies showed that female workers have menstrual dysfunction (menstrual irregularities in the form of hypomenorrhea, algomenorrhea, and irregular menstrual cycle were more often presented); absence of pregnancy in the first 5 years of the family life; hormonal disorders, there is also an activation of inflammatory responses, an increase in the immune reactivity; specific sensitization to acrylonitrile. Under conditions of production exposure to acrylonitrile, in workers there is observed an activation of autoimmune processes (increase in the level of antibodies to thyroid peroxidase (TPO), antibodies to phosphatidylserine), promoting lowering of immunological tolerance (elevation of antisperm antibodies), which has the impact on the formation of reproductive disorders (on fertilization and fetal development in the early stages of pregnancy), a high risk of abnormal pregnancy. The development of pathological processes of the cervix and breast is also associated with a deterioration of immunological reactivity and endocrine regulation. There was established a very high degree of the occupational conditionality of dyshormonal disorders (RR = 3.28, 95% CI = 1.22, EF = 69.48%); disorders of the menstrual cycle (RR = 4.63, 95% CI = 2.4–2.7, EF = 76.7%), the average degree of production conditionality of the pregnancy pathology (RR = 1.9, 95% CI = 1, 1–1,7, EF = 47,4%), pathological processes of the cervix (RR = 1.6, 95% CI = 1.3–1.7, EF = 37.5%), mastopathy (RR = 2.2, 95%, CI = 1,9–2.7, EF = 50%).