Features of the response of the blood system in phthalates production workers

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Abstract

Introduction. Phthalates are substances widely used as plasticizers for the production of various industrial, domestic, food and medical polymer materials. Possessing high volatility, solubility, a wide range of toxic effects, phthalates represent a serious danger to human health. Goal. Identify the characteristics of donosological forms of impaired health.

Material and methods. A special clinical and functional examination of the aparatics for the first time started their work in the production of terephthalic acid (TPA), purified terephthalic acid (oTPA) and polyethylene terephthalate (PET) in the dynamics of 5 years of operation of the enterprise POLYEF. Hygienic, hematological, cytochemical and biochemical studies were performed for workers with a primary 5-year experience in this industry.

Results. It is established that the chemical factor is represented by a complex of harmful substances of 1 to 4 hazard classes, among which there are substances of irritating, general toxic, allergenic action. The production of phthalates is characterized by an increased content of TPA from 1.5 to 2.8 MPC.

Discussion. The working conditions of the apparatchiks in all industries are estimated as harmful to the third degree — 3.3. Among those who have worked for 5 years, about a third of workers are recognized with clinical and functional disorders. For 5 years of work, two of the first three come into contact with phthalates revealed changes in the blood system that go beyond physiological fluctuations. Most workers have anemia, reticulocytosis, thrombocytopenia, eosinophilia, lymphocytosis, decreased activity of enzymes.

Conclusions. The introduction of a differentiated approach, taking into account the results of the clinical, hygienic and laboratory-diagnostic studies carried out, will allow monitoring of the health status of workers in the production of TFA and PET, identify early donosological signs of health disorders, and adequately form high-risk groups for conducting therapeutic and preventive measures.

About the authors

L. M. Karamova

Ufa Institute of Occupational Health and Human Ecology

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

V. O. Krasovsky

Ufa Institute of Occupational Health and Human Ecology

Email: noemail@neicon.ru
Russian Federation

G. R. Basharova

Bashkirian State Medical University

Email: noemail@neicon.ru
Russian Federation

Natalya V. Vlasova

Ufa Institute of Occupational Health and Human Ecology

Email: vnv.vlasova@yandex.ru

MD, Ph.D., biologist of the Clinical Biochemical laboratory of the Ufa Institute of Occupational Health and Human Ecology, 450008, Russian Federation.

e-mail: vnv.vlasova@yandex.ru

Russian Federation

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