Disorders of the immunoreactivity as a marker of professional risk to the health of workers in the production of vinyl chloride

Production of vinyl chloride (VC) is one of the largest world production of volume organic chemical intermediates, consumption of which, according to estimates from 2015 to 2020 will grow. Currently, the VC production involving more than 2 million people, the risk of formation of occupational and industrial-caused diseases might be significant. The purpose of this study was to evaluate the status of the immune reactivity of the organism of workers of different professional and experienced groups in the modern VC production to justify informative immunological criteria of the occupational health risk. There were performed the laboratory and immunological study of 77 men working in the VC production. The paper considers the regularities of formation of compensatory-adaptive immune responses in working in the VC production depending on the intensity and duration of exposure to adverse production factors. There is a more pronounced imbalance in the immune system workers of the main occupations (operatives, technicians) with long (10 or more years) experience. It characterized by a decrease in IL-2, IL-4, IgM and increased the production of IL-8, INF-α, TNF-α. The engineering staff experiencing less stress by toxicants, showed the compensatorily increased production of IL-1β and decrease of IgA and also unidirectional, but less pronounced changes in the content of IL-8, INF-γ. There is the relationship between the development of disorders in the immune system of workers in various occupational groups and the level of occupational risk for these specialties. Substantiated informative immunological parameters for the early detection of functional disorders of immune regulation underlying the formation of various diseases are necessary for the timely implementation of effective prevention programmes. Thus, the state of the immune reactivity of the body reflects the level of the adaptation potential of employees of various professions and experienced groups and may be an integrated assessment of the risk of violations of occupational health. The implementation of methods of immunodiagnostics will as predict and identify the disease at the early stages of its development that can optimize the resistance of the organism involved in the VC production as reducing the incidence.