Complex of hazard criteria for improvement of hygienic standards list of chemicals in water
- Autores: Mamonov R.A.1, Zholdakova Z.I.1, Sinitsyna O.O.1, Yudin S.M.1, Pechnikova I.A.1
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Afiliações:
- Center for Strategic Planning and Management of Biomedical Health Risks
- Edição: Volume 96, Nº 11 (2017)
- Páginas: 1099-1102
- Seção: PREVENTIVE TOXICOLOGY AND HYGIENIC STANDARTIZATION
- ##submission.datePublished##: 21.10.2020
- URL: https://ruspoj.com/0016-9900/article/view/640749
- DOI: https://doi.org/10.47470/0016-9900-2017-96-11-1099-1102
- ID: 640749
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Resumo
Analysis of domestic (Russian) and foreign documents revealed the necessity to correct existing standards of chemicals in water according to the new data about previously unexplored toxicological properties including mutagenic, carcinogenic effects, effects on the endocrine system. It is advisable to correct safety levels within the structural sets based on the relationship “structure – biotransformation – activity”. It is necessary to review critically the MACs of aromatic compounds substantiated on the organoleptic sign of harmfulness. The standards of nine carcinogens are proposed to revise with considering the classification and safety levels. Determination of threshold concentration on general sanitary index of harmfulness may be excluded from the regulation system because self-purification processes not sufficient in the Russian climatic conditions are related to ecological indices. This hazard index creates a discrepancy between the assessment of the danger of drinking and surface waters. It is necessary to create unified MACs for groups of substances in view of the forms of their presence in water and matching of toxic mechanism of action in compliance with the principle “unity of standard and method of control”.
Sobre autores
R. Mamonov
Center for Strategic Planning and Management of Biomedical Health Risks
Autor responsável pela correspondência
Email: noemail@neicon.ru
Rússia
Z. Zholdakova
Center for Strategic Planning and Management of Biomedical Health Risks
Email: noemail@neicon.ru
Rússia
O. Sinitsyna
Center for Strategic Planning and Management of Biomedical Health Risks
Email: noemail@neicon.ru
Rússia
S. Yudin
Center for Strategic Planning and Management of Biomedical Health Risks
Email: noemail@neicon.ru
Rússia
Irina Pechnikova
Center for Strategic Planning and Management of Biomedical Health Risks
Email: labtox430@mail.ru
MD, PhD, senior researcher of the Laboratory of ecologо-hygienic assessment and prediction of the toxicity of substances , “Center for Strategic Planning and Management of Biomedical Health Risks, Moscow, 119991, Russian Federation.
e-mail: labtox430@mail.ru
RússiaBibliografia
- Krasovskiy G.N., Zholdakova Z.I., Peshkov A.S., et al. Express-experimental methods for prediction of substances toxicity in water, based on the landmark scheme valuation. In: Hygienic Assessment of Harmful Substances in the Water: The Experience of Co-operation of the Comecon [Gigienicheskaya otsenka vrednykh veshchestv v vode: opyt sotrudnichestva stran-chlenov SEV]. Moscow; 1987: 137–45. (in Russian)
- Zholdakova Z.I., Sinitsyna O.O., Polyakova E.E. The problem of stability and transformation in complex hygienic rationing of chemicals. Gigiena i sanitariya. 2002; 81(6): 71–5. (in Russian)
- WHO. Guidelines for drinking-water quality. Geneva; 2011.
- Krasovskiy G.N., Egorova N.A. Harmonisation of hygienic standards with international requirements to the quality of drinking water. Gigiena i sanitariya. 2005; 84(2): 10–3. (in Russian)
- Zholdakova Z.I., Kharchevnikova N.V., Sinitsyna O.O. Current state of the issue of bisphenol A toxicity at exposure in doses close to those recognized safe. Toksikologicheskiy vestnik. 2012; (4): 19–25. (in Russian)
- Zholdakova Z.I., Kharchevnikova N.V. Prediction of the Hazard of Chemicals with Regard to Metabolism. Toxicol. Lett. 2000; 116(S1): 17.
- Zholdakova Z.I., Kharchevnikova N.V. A complex system for predicting substances toxicity and hazard based on the application of the structure-biotransformation-toxicity relationship. Toksikologicheskiy vestnik. 2013; (5): 33–5. (in Russian)
- Zholdakova Z.I., Kharchevnikova N.V. Forecast of safe levels of carcinogens in the water on the basis of the classification of carcinogenic risk. In: Proceedings of III Toxicologists Congress [Materialy III S’’ezda toksikologov]. Moscow; 2008: 118–9. (in Russian)
- Kharchevnikova N.V. Scientific basis for the forecast of the toxicity and hazards of chemicals consistent with the mechanism of the toxic effect: Diss. Moscow; 2011. (in Russian)
- Zholdakova Z.I., Zaytseva I.V., Stepanova M.B. Comparative study of the ability to transformation of anthraquinone derivatives in water. Gigiena i sanitariya. 1988; 67(1): 54–65. (in Russian)
- Zaytseva N.V., Zholdakova Z.I., Stepanova M.B. Calculation of threshold concentrations to influence the processes of self-purification of water bodies. Gigiena i sanitariya. 1987; 66(3): 14–5. (in Russian)
- Sinitsyna O.O., Zholdakova Z.I., Karamzin K.B., Tul’skaya E.A. Substantiation of generalized maximum allowable concentration of oxyethylidenediphosphonic acid and its derivatives in water. In: Proceedings of the 7th International Congress «Water: Ecology and Technology». Part II [Sbornik dokladov 7-go Mezhdunarodnogo kongressa «Voda: ekologiya i tekhnologiya». Chast’ II]. Moscow; 2006. (in Russian)
- Pechnikova I.A., Sinitsyna O.O., Zholdakova Z.I., Mamonov R.A. Comparative assessment of toxicity and danger sim-triazines in water for example derivatives of cyanuric acid and melamine. In: Proceedings of the VI Russian scientific-practical conference with international participation of young scientists and specialists «Environment and Health. Hygiene and Ecology of the urbanized territories», dedicated to the 85th anniversary of the State Organization «Institute of Human Ecology and Environmental Hygiene named after A.N. Sysin» of the Ministry of Health of Russia [Materialy VI Vserossiyskoy nauchno-prakticheskoy konferentsii s mezhdunarodnym uchastiem molodykh uchenykh i spetsialistov «Okruzhayushchaya sreda i zdorov’e. Gigiena i ekologiya urbanizirovannykh territoriy», posvyashchennaya 85-letiyu FGBU «NII ECh i GOS IM.A.N. Sysina» Minzdrava Rossii]. Moscow; 2016: 361–6. (in Russian)
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