Microfluidic-assisted synthesis of hybrid calcium carbonate/silver microparticles

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Resumo

The development of advanced methods for the synthesis of nano- and microparticles for biomedical applications is of considerable interest. A method for the synthesis of submicron silver-shelled calcium carbonate particles using a microfluidic chip designed to provide control over particle formation is proposed. Precise control of reaction parameters enables the formation of silver shell and calcium carbonate particles in a controlled manner. The distribution of pores in the hybrid particles was analyzed using small-angle X-ray scattering, which provided insight into the complex structure of the pores. The results provide information on particle morphology and may facilitate the development of new calcium carbonate-based materials for various applications.

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Sobre autores

А. Ermakov

Institute of Molecular Theranostics, First Moscow State Medical University (Sechenov University)

Email: trushina.d@mail.ru
Rússia, Moscow

S. Chapek

Southern Federal University

Email: trushina.d@mail.ru

The Smart Materials Research Institute

Rússia, Rostov-on-Don

Е. Lengert

Institute of Molecular Theranostics, First Moscow State Medical University (Sechenov University)

Email: trushina.d@mail.ru
Rússia, Moscow

P. Konarev

NRC “Kurchatov Institute”

Email: trushina.d@mail.ru

Shubnikov Institute of Crystallography of Kurchatov Complex of Crystallography and Photonics

Rússia, Moscow

V. Volkov

NRC “Kurchatov Institute”

Email: trushina.d@mail.ru

Shubnikov Institute of Crystallography of Kurchatov Complex of Crystallography and Photonics

Rússia, Moscow

M. Soldatov

Southern Federal University

Email: trushina.d@mail.ru

The Smart Materials Research Institute

Rússia, Rostov-on-Don

D. Trushina

Institute of Molecular Theranostics, First Moscow State Medical University (Sechenov University); NRC “Kurchatov Institute”

Autor responsável pela correspondência
Email: trushina.d@mail.ru

Shubnikov Institute of Crystallography of Kurchatov Complex of Crystallography and Photonics

Rússia, Moscow; Moscow

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2. Fig. 1. Topology of the microfluidic device (1 – transport phase inlet, 2 – reagent 1, 3 – reagent 2, 4 – reaction zone, 5 – droplet storage chamber, 6 – outlet, 7 – general view).

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3. Fig. 2. Micrograph of the plane of the microfluidic chip during the formation of CaCl2/Na2CO3 droplets in castor oil with the addition of 0.1 M AgNO3 and excess NH4OH, followed by washing with 5% glucose (C6H12O6).

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4. Fig. 3. SEM images of CaCO3 particles synthesized in the bulk phase using ethylene glycol (a) and CaCO3@Ag hybrid particles synthesized by the droplet method using a microfluidic device, in standard mode (b) and in combination with back-electron scattering mode (c).

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5. Fig. 4. DLS results for the distribution of CaCO3 particles synthesized in the bulk phase using ethylene glycol and CaCO3@Ag hybrid particles synthesized by the droplet method using a microfluidic device.

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6. Fig. 5. Experimental SAXS curves (a) and distribution functions Dv(r) (b) for CaCO3 synthesized in the bulk phase and inside the microfluidic chip during the formation of Ag NPs.

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7. Fig. 6. Antibacterial activity of hybrid vaterite CaCO3@Ag particles according to the standard minimum inhibitory concentration method (a) and the modified method: b – control, c – particles at a concentration of 10 particles per cell; as well as the viability of bacterial cells depending on the number of hybrid CaCO3@Ag particles added to the culture medium (d).

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