Nanodiamonds as lutetium-177 carriers for nuclear medicine

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

The work investigated the sorption of carrier-free 177Lu isolated from neutron-irradiated 176Yb2O3, and with a carrier obtained by irradiation of natLu2O3, by commercial and oxidized nanodiamonds (NDs) of various brands from aqueous solutions to identify among them a promising carrier for further research for the purposes of nuclear medicine. A promising sorbent was found: oxidized NDs of the STP brand (ox-STP); conditions for the rapid sorption of lutetium by it in an amount equivalent to 1.2 GBq of carrier-free 177Lu were determined, which corresponds to the activity used in therapy.

Full Text

Restricted Access

About the authors

A. G. Kazakov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Author for correspondence.
Email: adeptak92@mail.ru
Russian Federation, Moscow

J. S. Babenya

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Russian Federation, Moscow

T. Y. Ekatova

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Russian Federation, Moscow

S. E. Vinokurov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Russian Federation, Moscow

E. Y. Khvorostinin

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

Email: adeptak92@mail.ru
Russian Federation, Moscow

I. A. Ushakov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Russian Federation, Tomsk

V. V. Zukau

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Russian Federation, Tomsk

E. S. Stasyuk

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Russian Federation, Tomsk

E. A. Nesterov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Russian Federation, Tomsk

V. L. Sadkin

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Russian Federation, Tomsk

A. S. Rogov

National Research Tomsk Polytechnic University

Email: adeptak92@mail.ru
Russian Federation, Tomsk

B. F. Myasoedov

Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences; Interdepartmental Center for Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences

Email: adeptak92@mail.ru
Russian Federation, Moscow; Moscow

References

  1. Phua V.J.X., Yang C.-T., Xia B., Yan S.X., Liu J., Aw S.E. et al. // Nanomaterials. 2022. Vol. 12. N 4. Article 582.
  2. Islam W., Niidome T., Sawa T. // JPM. 2022. Vol. 12. N 12. Article 1964.
  3. Abd Elkodous M., El-Sayyad G.S., Abdelrahman I.Y., El-Bastawisy H.S., Mohamed A.E., Mosallam F.M. et al. // Colloids Surf. B: Biointerfaces. 2019. Vol. 180. P. 411–428.
  4. Lisik K., Krokosz A. // Int. J. Mol. Sci. 2021. Vol. 22. N 15. Article 8341.
  5. Bayda S., Hadla M., Palazzolo S., Kumar V., Caligiuri I., Ambrosi E. et al. // J. Controlled Release. 2017. Vol. 248. P. 144–152.
  6. Jeon J. // Int. J. Mol. Sci. 2019. Vol. 20. N 9. Article 2323.
  7. Matson M.L., Villa C.H., Ananta J.S., Law J.J., Scheinberg D.A., Wilson L.J. // J. Nucl. Med. 2015. Vol. 56. N 6. P. 897–900.
  8. Mulvey J.J., Villa C.H., McDevitt M.R., Escorcia F.E., Casey E., Scheinberg D.A. // Nature Nanotech. 2013. Vol. 8. N 10. P. 763–771.
  9. Chen L., Zhong X., Yi X., Huang M., Ning P., Liu T. et al. // Biomaterials. 2015. Vol. 66. P. 21–28.
  10. Peltek O.O., Muslimov A.R., Zyuzin M.V., Timin A.S. // J. Nanobiotechnol. 2019. Vol. 17. N 1. Article 90.
  11. Kazakov A.G., Garashchenko B.L., Yakovlev R.Y., Vinokurov S.E., Kalmykov S.N., Myasoedov B.F. // Diam. Relat. Mater. 2020. Vol. 104. Article 107752.
  12. Kazakov A.G., Garashchenko B.L., Yakovlev R.Y., Vinokurov S.E., Myasoedov B.F. // Radiochemistry. 2020. Vol. 62. P. 752–758.
  13. Kazakov A.G., Garashchenko B.L., Ivanova M.K., Vinokurov S.E., Myasoedov B.F. // Nanomaterials. 2020. Vol. 10. N 6. Article 1090.
  14. Babenya J.S., Kazakov A.G., Ekatova T.Y., Yakovlev R.Y. // J. Radioanal. Nucl. Chem. 2021. Vol. 329. N 2. P. 1027–1031.
  15. Turcheniuk K., Mochalin V.N. // Nanotechnology. 2017. Vol. 28. N 25. Article 252001.
  16. Jović D., Jaćević V., Kuča K., Borišev I., Mrdjanovic J., Petrovic D. et al. // Nanomaterials. 2020. Vol. 10. N 8. Article 1508.
  17. Chung P.-H., Perevedentseva E., Tu J.-S., Chang C.C., Cheng C.-L. // Diam. Relat. Mater. 2006. Vol. 15. P. 622–625.
  18. Tsai L.-W., Lin Y.-C., Perevedentseva E., Lugovtsov A., Priezzhev A., Cheng C. L. // Int. J. Mol. Sci. 2016. Vol. 17. N 7. Article 1111.
  19. Winter G., Eberhardt N., Löffler J., Raabe M., Alam M.N.A., Hao L. et al. // Nanomaterials. 2022. Vol. 12. N 24. Article 4471.
  20. Burkett B.J., Dundar A., Young J.R., Packard A.T., Johnson G.B., Halfdanarson T.R. et al. // Radiology. 2021. Vol. 298. N 2. P. 261–274.
  21. Kazakov A.G., Babenya J.S., Ekatova T.Y., Vinokurov S. E., Myasoedov B.F. // Advances in Geochemistry, Analytical Chemistry and Planetary Sciences. 2023. P. 595–601.
  22. Yakovlev R.Y., Dogadkin N.N., Kulakova I.I., Lisichkin G.V., Leonidov N.B., Kolotov V.P. // Diam. Relat. Mater. 2015. Vol. 55. P. 77–86.
  23. Karpukhin A.V., Avkhacheva N.V., Yakovlev R.Y., Kulakova I.I., Yashin V.A., Lisichkin G.V., Safronova V.G. // Cell. Biol. Int. 2011. Vol. 35. N 7. P. 727–733.
  24. Dolmatov V.Y., Rudenko D.V., Burkat G.K., Aleksandrova A.S., Vul’ A.Yu., Aleksenskii A.E. et al. // J. Superhard Mater. 2019. Vol. 41. N 3. P. 169–177.
  25. Yeap W.S., Tan Y.Y., Loh K.P. // Anal. Chem. 2008. Vol. 80. N 12. P. 4659–4665.
  26. Inagaki M., Sekimoto, S., Tanaka, W., Tadokoro Т., Ueno Y., Kani Y., Tsutomu O. // J. Radioanal. Nucl. Chem. 2019. Vol. 322. P. 1703–1709.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Elution curve of 177Lu-bn without carrier and Yb with α-HIBA solution on a Dowex 50WX8 column.

Download (107KB)
Indexing metadata
3. Fig. 2. Sorption of 177Lu-bn by TAN (a) and ok-TAN (b) samples, 100 μg/ml

Download (141KB)
Indexing metadata
4. Fig. 3. Sorption of 177Lu-bn TAN and ox-TAN at pH 5.6 for 5 min depending on the m/V ratio.

Download (78KB)
Indexing metadata
5. Fig. 4. Sorption of 177Lu-sn (20 ng) by TAN sample, 100 μg/ml.

Download (104KB)
Indexing metadata
6. Fig. 5. Sorption of 177Lu-sn (20 ng) by STP (a) and ox-STP (b) samples, 100 μg/ml.

Download (154KB)
Indexing metadata
7. Fig. 6. Sorption of 177Lu-sn (20 ng) by STP and ox-STP samples at pH 5.6 for 30 min depending on the m/V ratio.

Download (77KB)
Indexing metadata
8. Fig. 7. Sorption of 177Lu-sn (300 ng) by ox-STP at pH 5.6 depending on the m/V ratio.

Download (85KB)
Indexing metadata

Copyright (c) 2024 Russian Academy of Sciences