Nanodiamonds as lutetium-177 carriers for nuclear medicine
- Authors: Kazakov A.G.1, Babenya J.S.1, Ekatova T.Y.1, Vinokurov S.E.1, Khvorostinin E.Y.1, Ushakov I.A.2, Zukau V.V.2, Stasyuk E.S.2, Nesterov E.A.2, Sadkin V.L.2, Rogov A.S.2, Myasoedov B.F.1,3
-
Affiliations:
- Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
- National Research Tomsk Polytechnic University
- Interdepartmental Center for Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences
- Issue: Vol 66, No 2 (2024)
- Pages: 171-177
- Section: Articles
- URL: https://ruspoj.com/0033-8311/article/view/661161
- DOI: https://doi.org/10.31857/S0033831124020088
- ID: 661161
Cite item
Abstract
The work investigated the sorption of carrier-free 177Lu isolated from neutron-irradiated 176Yb2O3, and with a carrier obtained by irradiation of natLu2O3, by commercial and oxidized nanodiamonds (NDs) of various brands from aqueous solutions to identify among them a promising carrier for further research for the purposes of nuclear medicine. A promising sorbent was found: oxidized NDs of the STP brand (ox-STP); conditions for the rapid sorption of lutetium by it in an amount equivalent to 1.2 GBq of carrier-free 177Lu were determined, which corresponds to the activity used in therapy.
Keywords
Full Text

About the authors
A. G. Kazakov
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: adeptak92@mail.ru
Russian Federation, Moscow
J. S. Babenya
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Email: adeptak92@mail.ru
Russian Federation, Moscow
T. Y. Ekatova
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Email: adeptak92@mail.ru
Russian Federation, Moscow
S. E. Vinokurov
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Email: adeptak92@mail.ru
Russian Federation, Moscow
E. Y. Khvorostinin
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Email: adeptak92@mail.ru
Russian Federation, Moscow
I. A. Ushakov
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
V. V. Zukau
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
E. S. Stasyuk
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
E. A. Nesterov
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
V. L. Sadkin
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
A. S. Rogov
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
B. F. Myasoedov
Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences; Interdepartmental Center for Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences
Email: adeptak92@mail.ru
Russian Federation, Moscow; Moscow
References
- Phua V.J.X., Yang C.-T., Xia B., Yan S.X., Liu J., Aw S.E. et al. // Nanomaterials. 2022. Vol. 12. N 4. Article 582.
- Islam W., Niidome T., Sawa T. // JPM. 2022. Vol. 12. N 12. Article 1964.
- Abd Elkodous M., El-Sayyad G.S., Abdelrahman I.Y., El-Bastawisy H.S., Mohamed A.E., Mosallam F.M. et al. // Colloids Surf. B: Biointerfaces. 2019. Vol. 180. P. 411–428.
- Lisik K., Krokosz A. // Int. J. Mol. Sci. 2021. Vol. 22. N 15. Article 8341.
- Bayda S., Hadla M., Palazzolo S., Kumar V., Caligiuri I., Ambrosi E. et al. // J. Controlled Release. 2017. Vol. 248. P. 144–152.
- Jeon J. // Int. J. Mol. Sci. 2019. Vol. 20. N 9. Article 2323.
- Matson M.L., Villa C.H., Ananta J.S., Law J.J., Scheinberg D.A., Wilson L.J. // J. Nucl. Med. 2015. Vol. 56. N 6. P. 897–900.
- Mulvey J.J., Villa C.H., McDevitt M.R., Escorcia F.E., Casey E., Scheinberg D.A. // Nature Nanotech. 2013. Vol. 8. N 10. P. 763–771.
- Chen L., Zhong X., Yi X., Huang M., Ning P., Liu T. et al. // Biomaterials. 2015. Vol. 66. P. 21–28.
- Peltek O.O., Muslimov A.R., Zyuzin M.V., Timin A.S. // J. Nanobiotechnol. 2019. Vol. 17. N 1. Article 90.
- Kazakov A.G., Garashchenko B.L., Yakovlev R.Y., Vinokurov S.E., Kalmykov S.N., Myasoedov B.F. // Diam. Relat. Mater. 2020. Vol. 104. Article 107752.
- Kazakov A.G., Garashchenko B.L., Yakovlev R.Y., Vinokurov S.E., Myasoedov B.F. // Radiochemistry. 2020. Vol. 62. P. 752–758.
- Kazakov A.G., Garashchenko B.L., Ivanova M.K., Vinokurov S.E., Myasoedov B.F. // Nanomaterials. 2020. Vol. 10. N 6. Article 1090.
- Babenya J.S., Kazakov A.G., Ekatova T.Y., Yakovlev R.Y. // J. Radioanal. Nucl. Chem. 2021. Vol. 329. N 2. P. 1027–1031.
- Turcheniuk K., Mochalin V.N. // Nanotechnology. 2017. Vol. 28. N 25. Article 252001.
- Jović D., Jaćević V., Kuča K., Borišev I., Mrdjanovic J., Petrovic D. et al. // Nanomaterials. 2020. Vol. 10. N 8. Article 1508.
- Chung P.-H., Perevedentseva E., Tu J.-S., Chang C.C., Cheng C.-L. // Diam. Relat. Mater. 2006. Vol. 15. P. 622–625.
- Tsai L.-W., Lin Y.-C., Perevedentseva E., Lugovtsov A., Priezzhev A., Cheng C. L. // Int. J. Mol. Sci. 2016. Vol. 17. N 7. Article 1111.
- Winter G., Eberhardt N., Löffler J., Raabe M., Alam M.N.A., Hao L. et al. // Nanomaterials. 2022. Vol. 12. N 24. Article 4471.
- Burkett B.J., Dundar A., Young J.R., Packard A.T., Johnson G.B., Halfdanarson T.R. et al. // Radiology. 2021. Vol. 298. N 2. P. 261–274.
- Kazakov A.G., Babenya J.S., Ekatova T.Y., Vinokurov S. E., Myasoedov B.F. // Advances in Geochemistry, Analytical Chemistry and Planetary Sciences. 2023. P. 595–601.
- Yakovlev R.Y., Dogadkin N.N., Kulakova I.I., Lisichkin G.V., Leonidov N.B., Kolotov V.P. // Diam. Relat. Mater. 2015. Vol. 55. P. 77–86.
- Karpukhin A.V., Avkhacheva N.V., Yakovlev R.Y., Kulakova I.I., Yashin V.A., Lisichkin G.V., Safronova V.G. // Cell. Biol. Int. 2011. Vol. 35. N 7. P. 727–733.
- Dolmatov V.Y., Rudenko D.V., Burkat G.K., Aleksandrova A.S., Vul’ A.Yu., Aleksenskii A.E. et al. // J. Superhard Mater. 2019. Vol. 41. N 3. P. 169–177.
- Yeap W.S., Tan Y.Y., Loh K.P. // Anal. Chem. 2008. Vol. 80. N 12. P. 4659–4665.
- Inagaki M., Sekimoto, S., Tanaka, W., Tadokoro Т., Ueno Y., Kani Y., Tsutomu O. // J. Radioanal. Nucl. Chem. 2019. Vol. 322. P. 1703–1709.
Supplementary files
