Email this article Preparation of suspension of nanodiamonds with immobilized scandium isotopes for in vivo research
- Authors: Kazakov A.G.1, Pavlova D.V.1,2, Ushakov I.A.3, Nesterov E.A.3, Skuridin V.S.3, Odintsova E.A.4, Vinokurov S.E.1, Myasoedov B.F.1,5
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Affiliations:
- Vernadsky Institute of Geochemistry and Analytical Chemistry, RAS
- Mendeleev University of Chemical Technology of Russia
- National Research Tomsk Polytechnic University
- Bentonit Company
- Interdepartmental Center for Analytical Research in Physics, Chemistry, and Biology, RAS
- Issue: Vol 66, No 6 (2024)
- Pages: 582-588
- Section: Articles
- URL: https://ruspoj.com/0033-8311/article/view/681272
- DOI: https://doi.org/10.31857/S0033831124060097
- ID: 681272
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Abstract
The conditions for preparing a suspension of detonation synthesis nanodiamonds (NDs) with immobilized scandium in solutions that meet the requirements to solutions for intravenous administration of radiopharmaceuticals (RPs) based on 44Sc and 47Sc are determined. The possibility of quantitatively binding scandium by ND samples in isotonic solutions with the required pH, containing a minimum amount of NDs, is demonstrated. The parameters of the Freundlich and Langmuir adsorption isotherms and ΔG of adsorption under optimal conditions for the most promising ND sample are determined. The conditions found for obtaining NDs with immobilized scandium isotopes will allow further in vivo researches.
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About the authors
A. G. Kazakov
Vernadsky Institute of Geochemistry and Analytical Chemistry, RAS
Author for correspondence.
Email: adeptak92@mail.ru
Russian Federation, Moscow
D. V. Pavlova
Vernadsky Institute of Geochemistry and Analytical Chemistry, RAS; Mendeleev University of Chemical Technology of Russia
Email: adeptak92@mail.ru
Russian Federation, Moscow; Moscow
I. A. Ushakov
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
E. A. Nesterov
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
V. S. Skuridin
National Research Tomsk Polytechnic University
Email: adeptak92@mail.ru
Russian Federation, Tomsk
E. A. Odintsova
Bentonit Company
Email: adeptak92@mail.ru
Russian Federation, Moscow
S. E. Vinokurov
Vernadsky Institute of Geochemistry and Analytical Chemistry, RAS
Email: adeptak92@mail.ru
Russian Federation, Moscow
B. F. Myasoedov
Vernadsky Institute of Geochemistry and Analytical Chemistry, RAS; Interdepartmental Center for Analytical Research in Physics, Chemistry, and Biology, RAS
Email: adeptak92@mail.ru
Russian Federation, Moscow; Moscow
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