“2+1B” Technetium-99m Tricarbonyl Complexes with N,N'-Bidentate Ligands and Methyl 14-Isocyano-3-Methyltetradecanoate

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Abstract

A novel procedure was developed for preparing methyl 14-isocyano-3-methyltetradecanoate. It consists of 12 steps. “2+1B” tricarbonyl complexes [99mTc(CO)3(N^N)CN(CH2)11CH(CH3) CH2COOMe]+, where N^N = 2,2’-bipyridine (bipy) or 1,10-phenanthroline (phen), were prepared by the reaction of [99mTc(CO)3(N^N)(H2O,EtOH)]+ with methyl 14-isocyano-3-methyltetradecanoate in aqueous ethanol. The formation of technetium-99m complexes was confirmed by HPLC, and the partition coefficient (n-octanol/water) of these complexes was measured.

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About the authors

A. E. Miroslavov

Khlopin Radium Institute; St. Petersburg State University; Ozyorsk Institute of Technology, Branch of National Research Nuclear University MEPhI

Email: gevasid@mail.ru
Russian Federation, 2-i Murinskii pr. 28, St. Petersburg, 194021; Universitetskaya nab. 7/9, St. Petersburg, 199034; pr. Pobedy 48, Ozyorsk, Chelyabinsk oblast, 456783

P. M. Kuz’menko

St. Petersburg State University

Email: gevasid@mail.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034

M. Yu. Tyupina

Khlopin Radium Institute; Ozyorsk Institute of Technology, Branch of National Research Nuclear University MEPhI

Email: gevasid@mail.ru
Russian Federation, 2-i Murinskii pr. 28, St. Petersburg, 194021; pr. Pobedy 48, Ozyorsk, Chelyabinsk oblast, 456783

A. P. Sakhonenkova

Khlopin Radium Institute; Ozyorsk Institute of Technology, Branch of National Research Nuclear University MEPhI

Email: gevasid@mail.ru
Russian Federation, 2-i Murinskii pr. 28, St. Petersburg, 194021; pr. Pobedy 48, Ozyorsk, Chelyabinsk oblast, 456783

G. V. Sidorenko

Khlopin Radium Institute; Ozyorsk Institute of Technology, Branch of National Research Nuclear University MEPhI

Author for correspondence.
Email: gevasid@mail.ru
Russian Federation, 2-i Murinskii pr. 28, St. Petersburg, 194021; pr. Pobedy 48, Ozyorsk, Chelyabinsk oblast, 456783

A. R. Kochergina

Khlopin Radium Institute; Ozyorsk Institute of Technology, Branch of National Research Nuclear University MEPhI; Ozyorsk Institute of Technology, Branch of National Research Nuclear University MEPhI

Email: gevasid@mail.ru
Russian Federation, 2-i Murinskii pr. 28, St. Petersburg, 194021; pr. Pobedy 48, Ozyorsk, Chelyabinsk oblast, 456783; pr. Pobedy 48, Ozyorsk, Chelyabinsk oblast, 456783

S. A. Krotov

Khlopin Radium Institute

Email: gevasid@mail.ru
Russian Federation, 2-i Murinskii pr. 28, St. Petersburg, 194021

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Supplementary files

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2. Fig. 1. HPLC chromatogram of [99mTcI(CO)5].

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3. Fig. 2. Chromatogram of [99mTc(CO)3(H2O)3]+ (Rt = 5.38 min at p = 130.5 bar).

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4. Scheme 1. Procedure for the synthesis of the methyl ester of 14-isocyano-3-methyltetradecanoic acid.

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5. Fig. 3. NMR spectrum of HCl-H2N(CH2)11CH(CH3) CH2COOMe.

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6. Scheme 2. Synthesis procedure for [99mTc(CO)3(N^N)(CN(CH2)11CH(CH3) COOMe)]+, where N^N = bipy (13a) or phen (13b).

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7. Fig. 4. HPLC chromatogram of the reaction mixture of the synthesis of [99mTc(CO)3(bipy)(CN(CH2)11CH(CH3) COOMe)]+.

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8. Fig. 5. HPLC chromatogram of the reaction mixture of the synthesis of [99mTc(CO)3(phen)(CN(CH2)11CH(CH3) COOMe)]+.

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9. Supplementary
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