“2+1B” Technetium-99m Tricarbonyl Complexes with N,N'-Bidentate Ligands and Methyl 14-Isocyano-3-Methyltetradecanoate
- Authors: Miroslavov A.E.1,2,3, Kuz’menko P.M.2, Tyupina M.Y.1,3, Sakhonenkova A.P.1,3, Sidorenko G.V.1,3, Kochergina A.R.1,3, Krotov S.A.1
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Affiliations:
- Khlopin Radium Institute
- St. Petersburg State University
- Ozyorsk Institute of Technology, Branch of National Research Nuclear University MEPhI
- Issue: Vol 66, No 5 (2024)
- Pages: 438-446
- Section: Articles
- URL: https://ruspoj.com/0033-8311/article/view/681304
- DOI: https://doi.org/10.31857/S0033831124050039
- ID: 681304
Cite item
Abstract
A novel procedure was developed for preparing methyl 14-isocyano-3-methyltetradecanoate. It consists of 12 steps. “2+1B” tricarbonyl complexes [99mTc(CO)3(N^N)CN(CH2)11CH(CH3) CH2COOMe]+, where N^N = 2,2’-bipyridine (bipy) or 1,10-phenanthroline (phen), were prepared by the reaction of [99mTc(CO)3(N^N)(H2O,EtOH)]+ with methyl 14-isocyano-3-methyltetradecanoate in aqueous ethanol. The formation of technetium-99m complexes was confirmed by HPLC, and the partition coefficient (n-octanol/water) of these complexes was measured.
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About the authors
A. E. Miroslavov
Khlopin Radium Institute; St. Petersburg State University; Ozyorsk Institute of Technology, Branch of National Research Nuclear University MEPhI
Email: gevasid@mail.ru
Russian Federation, 2-i Murinskii pr. 28, St. Petersburg, 194021; Universitetskaya nab. 7/9, St. Petersburg, 199034; pr. Pobedy 48, Ozyorsk, Chelyabinsk oblast, 456783
P. M. Kuz’menko
St. Petersburg State University
Email: gevasid@mail.ru
Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034
M. Yu. Tyupina
Khlopin Radium Institute; Ozyorsk Institute of Technology, Branch of National Research Nuclear University MEPhI
Email: gevasid@mail.ru
Russian Federation, 2-i Murinskii pr. 28, St. Petersburg, 194021; pr. Pobedy 48, Ozyorsk, Chelyabinsk oblast, 456783
A. P. Sakhonenkova
Khlopin Radium Institute; Ozyorsk Institute of Technology, Branch of National Research Nuclear University MEPhI
Email: gevasid@mail.ru
Russian Federation, 2-i Murinskii pr. 28, St. Petersburg, 194021; pr. Pobedy 48, Ozyorsk, Chelyabinsk oblast, 456783
G. V. Sidorenko
Khlopin Radium Institute; Ozyorsk Institute of Technology, Branch of National Research Nuclear University MEPhI
Author for correspondence.
Email: gevasid@mail.ru
Russian Federation, 2-i Murinskii pr. 28, St. Petersburg, 194021; pr. Pobedy 48, Ozyorsk, Chelyabinsk oblast, 456783
A. R. Kochergina
Khlopin Radium Institute; Ozyorsk Institute of Technology, Branch of National Research Nuclear University MEPhI; Ozyorsk Institute of Technology, Branch of National Research Nuclear University MEPhI
Email: gevasid@mail.ru
Russian Federation, 2-i Murinskii pr. 28, St. Petersburg, 194021; pr. Pobedy 48, Ozyorsk, Chelyabinsk oblast, 456783; pr. Pobedy 48, Ozyorsk, Chelyabinsk oblast, 456783
S. A. Krotov
Khlopin Radium Institute
Email: gevasid@mail.ru
Russian Federation, 2-i Murinskii pr. 28, St. Petersburg, 194021
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