Abstract
[3H]Hyaluronic acid with a molecular weight of 2.37 MDa and a specific radioactivity of 35 GBq/g was obtained using the tritium thermal activation method. Tritium labelled preparations of hyaluronic acid (HA) with a molecular weight of 2.37, 0.20 and 0.10 MDa were used to study their adsorption on hydroxyapatite (HAP) in two textural modifications: aqueous suspension and powder. Differences in adsorption kinetics and adsorption isotherms were observed due to variations in the interaction between polysaccharide molecules and the sorbent forms under consideration. The adsorption isotherms of HA on HAP turned out to be linear. It is shown that strong HA-CAP complexes are formed, and no desorption of HA into water and 0.9% NaCl solution was detected in 2 days.