The effectiveness of respiratory support in the early period of intoxication of rabbits with products of thermal degradation of fluoroplast-4

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Abstract

Inhalation intoxication with acylating pulmonotoxicants (phosgene, perfluoroisobutylene) leads to the formation of toxic pulmonary edema, pharmacological approaches to the treatment of which are ineffective. Respiratory therapy is successfully used to treat non-toxic pulmonary edema. Data on the effectiveness of respiratory support in toxic pulmonary edema are limited. The aim of the study was to experimentally evaluate the effectiveness of protective ventilation with positive end-expiratory pressure in the early period of intoxication by products of thermal degradation of fluoroplast-4. Early initiation of protective ventilation with positive end-expiratory pressure proved to be effective for the correction of toxic pulmonary edema in rabbits in the early period of intoxication by products of thermal degradation of fluoroplast-4 with pulmonotoxic effects. Respiratory support may be an effective approach for the treatment of toxic pulmonary edema caused by intoxication with acylating pulmonotoxicants.

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About the authors

P. G. Tolkach

Kirov Military Medical Academy

Author for correspondence.
Email: pgtolkach@gmail.com
Russian Federation, St. Petersburg

D. M. Yaroshenko

Kirov Military Medical Academy

Email: pgtolkach@gmail.com
Russian Federation, St. Petersburg

A. A. Khovpachev

Kirov Military Medical Academy

Email: pgtolkach@gmail.com
Russian Federation, St. Petersburg

D. T. Sizova

Kirov Military Medical Academy

Email: pgtolkach@gmail.com
Russian Federation, St. Petersburg

Yu. D. Ilatovskaya

Veterinary clinic of oncology, traumatology and intensive care of Dr. Sotnikov

Email: pgtolkach@gmail.com
Russian Federation, St. Petersburg

G. U. Gracheva

Veterinary clinic of oncology, traumatology and intensive care of Dr. Sotnikov; St. Petersburg State University of veterinary medicine

Email: pgtolkach@gmail.com
Russian Federation, St. Petersburg; St. Petersburg

V. A. Basharin

Kirov Military Medical Academy

Email: pgtolkach@gmail.com
Russian Federation, St. Petersburg

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2. Fig. 1. (a) — blood hemoglobin saturation; (b) — partial pressure of carbon dioxide in exhaled air (PeCO2) of rabbits, determined during respiratory support, Me.

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3. Fig. 2. Pulmonary coefficient of rabbits 6 hours after exposure against the background of protective mechanical ventilation with PEEP, relative units, Me [Q1; Q2]. Notes: in each group n = 3; * — differences are significant, compared with the control group, p < 0.05; # — differences are significant, compared with the intoxication group, p < 0.05.

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