Determination of the Stability Constants of Supramolecular Complexes of Ester Derivatives of Betulin with Randomly Methylated β-Cyclodextrin by Affinity Capillary Electrophoresis

V. V. Sursyakova; Сурсякова В. В.; V. A. Levdansky; Левданский В. А.; A. I. Rubaylo; Рубайло А. И.

doi:10.31857/S0044453723100230

Determination of the Stability Constants of Supramolecular Complexes of Ester Derivatives of Betulin with Randomly Methylated β-Cyclodextrin by Affinity Capillary Electrophoresis

Autores: Sursyakova V.V.¹, Levdansky V.A.¹, Rubaylo A.I.¹^,2
Afiliações:
1. Institute of Chemistry and Chemical Technology, Federal Research Center “Krasnoyarsk Scientific Center,” Siberian Branch, Russian Academy of Sciences
2. Siberian Federal University
Edição: Volume 97, Nº 10 (2023)
Páginas: 1464-1470
Seção: PHYSICAL CHEMISTRY OF NANOCLUSTERS, SUPRAMOLECULAR STRUCTURES, AND NANOMATERIALS
##submission.dateSubmitted##: 26.02.2025
##submission.datePublished##: 01.10.2023
URL: https://ruspoj.com/0044-4537/article/view/668644
DOI: https://doi.org/10.31857/S0044453723100230
EDN: https://elibrary.ru/PTZXWM
ID: 668644

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Resumo

Using affinity capillary electrophoresis, the stability constants of inclusion complexes of a number of betulin ester derivatives with randomly methylated β-cyclodextrin in 0.0100 M sodium tetraborate (pH 9.18, ionic strength 0.0200 M) at 25°С were determined for the first time. The decimal logarithms of the stability constants of 1 : 1 complexes of betulin 3,28-diphthalate, betulin 3,28-disulfate, and betulin 3,28-disuccinate in a 95% confidence interval were 4.64 ± 0.05, 4.78 ± 0.02, and 4.94 ± 0.02, respectively. The logarithms of the stability constants of 1 : 2 complexes of betulin 3,28-diphthalate and betulin 3,28-disulfate were 7.91 (6.66–8.19) and 8.02 (7.63–8.23), respectively. It was determined that betulin 3,28-disuccinate forms only 1 : 1 complex. The obtained stability constants of 1 : 1 complexes are generally higher than those of the complexes of the same compounds with β-cyclodextrin (β-CD) and lower than those for dimethyl-β-CD, γ-CD, and (2-hydroxypropyl)-γ-CD complexes.

Palavras-chave

inclusion complexes, triterpenoids of the lupane series, capillary electrophoresis, binding constant, formation constant, association constant

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