Resonance Electron Capture by 5-Methyluridine and 3'-Deoxythymidine Molecules

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Resumo

Negative ion mass spectrometry is used to study processes of resonant electron attachment by 5‑methyluridine and 3'-deoxythymidine nucleoside molecules in the electron 0–14 eV range of energies. It is established that they are similar to those in nucleosides studied earlier (uridine, deoxyuridine, thymidine). The main channels of the fragmentation of molecular ions are revealed, and the absolute cross sections for the formation of fragment ions are determined. It is found that the intensity of the breaking the glycosidic bond in 3'-deoxythymidine in the region of low energies is two and a half orders of magnitude below the one in stavudine, testifying to the prospect of replacing the antiretroviral drug stavudine with 3'-deoxythymidine if radiation therapy is required for oncological diseases contracted as complications of HIV.

Sobre autores

M. Muftakhov

Institute of Molecule and Crystal Physics, Ufa Federal Research Center, Russian Academy of Sciences

Email: LMSNI@anrb.ru
450075, Ufa, Russia

R. Tuktarov

Institute of Molecule and Crystal Physics, Ufa Federal Research Center, Russian Academy of Sciences

Autor responsável pela correspondência
Email: LMSNI@anrb.ru
450075, Ufa, Russia

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Declaração de direitos autorais © М.В. Муфтахов, Р.Ф. Туктаров, 2023