Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains in vitro due to zinc(II) complexation

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Abstract

This article proposes carbocyclic derivatives of N-acylated esters of L-amino acids with aromatic carboxylic acids as antiviral low-molecular agents. To increase the water solubility of inhibitors that are insoluble in aqueous solutions, the target compounds were used in the form of zinc(II) complexes. It has been shown that hydrophobic organic compounds in the form of zinc(II)-coordinated ligands are capable of suppressing the replication of an influenza A virus strain resistant to adamantane-type drugs. Zinc(II) chloride at the concentration used does not have antiviral or toxic effects in experiments in vitro.

About the authors

Т. М. Garaev

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow

I. I. Yudin

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow

N. V. Breslav

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow

Т. Е. Savochkina

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow

А. S. Krepkaya

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow

Т. V. Grebennikova

National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya, Ministry of Health of the Russian Federation

Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow

S. Е. Nikiforova

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow

I. I. Myshletsov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow

V. V. Avdeeva

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Author for correspondence.
Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow

Е. А. Malinina

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: avdeeva.varvara@mail.ru
Russian Federation, Moscow

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