Synthesis and effect of substituted pyrido[2,3-d]pyrimidine-2,4-diones on In Vitro tumor dna methylation

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Reaction of 3-diethylamino-1-aryl-, 3-diethylamino-1-aryl-2-phenyl(4-halophenyl)propane-1-ones hydrochlorides with 6-amino-1,3-dimethyluracil results in heterocyclization products, namely 1,3-dimethyl-7-aryl-5,6dihydro-1 H -pyrido[2,3- d ]pyrimidine-2,4-diones, 1,3-dimethyl-7-aryl-6-phenyl(4-halophenyl)-5,6-dihydro1 H -pyrido[2,3- d ]pyrimidine-2,4-diones and 1,3-dimethyl-7-aryl-6-phenyl-(4-halophenyl)-1 H -pyrido[2,3- d ] pyrimidine-2,4-diones. The effect of the synthesized compounds in vitro tumor DNA methylation was studied.

About the authors

A. U Isakhanyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru

N. Z Hakobyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Z. A Hovasyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

L. E Nersesyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

A. S Aharonyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

I. S Danielyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

H. A Panosyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

A. A Harutyunyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

References

  1. Мещерякова С.А. Дисс. … докт. фарм. наук. Уфа, 2015.
  2. Fares M., Abou-Seri S.M., Abdel-Aziz H.A., Abbas S.E., Youssef M.M., Eladwy R.A. // Eur. J. Med. Chem. 2014. Vol. 83. P. 155. doi: 10.1016/j.ejmech.2014.06.027
  3. Abadi A.H., Hany M.S., Elsharif S.A., Eissa A.A., Gary B.D., Tinsley H.N., Piazza G.A. // Chem. Pharm. Bull. 2013. Vol. 61. N 4. P. 405. doi: 10.1248/cpb.c12-00993
  4. Vanyushin B.F. // JSM Genet. Genomics. 2016. Vol. 3. N 1. P. 1010.
  5. Azad N., Zahnow C.A., Rudin C.M., Baylin S.B. // Nat. Rev. Clin. Oncol. 2013. Vol. 10. N 5. P 256. doi: 10.1038/nrclinonc.2013.42
  6. Геворгян Г.А., Авакян А.П., Агабабян А.Г., Акопян Н.З., Маркарян Т.А., Паносян Г.А. // Хим. ж. Армении. 2013. T. 66. № 4. С. 597.
  7. Baylin S.B., Herman J.G. // Trends Genetics. 2000. Vol. 16. N 4. P. 168.
  8. Howell P.M., Jr., Liu Z., Khong H.T. // Pharmaceuticals. 2010. Vol. 3. N 7. P. 2022. doi: 10.3390/ph3072022
  9. Геворгян Г.А., Авакян А.П., Гаспарян Н.К., Паносян Г.А. // ЖОрХ. 2009. Т. 45. С. 1854
  10. Gevorgyan G.A., Avakyan A.P., Gasparyan N.K., Panosyan G.A. // Russ. J. Org. Chem. 2009. Vol. 45. P. 1853. doi: 10.1134/S1070428009120173
  11. Vanyushin B.F., Masin A.L., Vasiliev V.K., Belozersky A.N. // Biochim. Biophys. Acta. 1973. Vol. 299. N 3. P. 397. doi: 10.1016/0005-2787(73)90264-5

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2023 Russian Academy of Sciences