Volume 95, Nº 3-4 (2025)

A series of 19 derivatives of sulfanilamide was synthesized by the reaction of chloroacetamide, trichloroacetamide and chloropropionamide with N-nucleophiles. It was shown that N-trichloroacetylsulfanilamide in reactions with amines forms products of substitution of the trichloromethyl group, while N-chloroacetylsulfanilamide and N-chloropropionylsulfanilamide react with substitution of the halogen atom. An assessment of the antibacterial properties of the synthesized structures was carried out, showing the absence of activity with respect to E. coli and St. aureus strains. Two aminoalkyl-containing sulfonamides – 2-(4-benzylpiperidin-1-yl)-N-(4-sulfamoylphenyl)acetamide and 2-(4-nitropyrazol-1-yl)-N-(4-sulfamoylphenyl)acetamide – showed inhibitory properties against the human monoamine oxidase enzyme, comparable in IC₅₀ value to the drug zonisamide.

4-[(4-Аroyl-2,6,8,10-tetraoxo-1-oxa-7,9-diazaspiro[4.5]dec-3-en-3-yl)amino]benzoic acids were synthesized by reacting 4-{[(2Z)-4-aryl-1-methoxy-1,4-dioxobut-2-en-2-yl]amino}benzoic acids with alloxan in glacial acetic acid. The structure of the obtained compounds was confirmed by IR, ¹H and ¹³C{¹H} NMR spectroscopy. The antioxidant activity of the synthesized compounds was studied.

4-Aryl-3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-2(1H)-ones were obtained by the reaction of dimethyl malonate (diethyl malonate), aromatic aldehyde, and 1H-benzimidazole-2-amine in methanol (ethanol) in the presence of piperidine for 6 h. Structure of the compounds was confirmed by ¹H, ¹³C NMR spectroscopy and X-ray diffraction analysis. Antioxidant activity of the synthesized compounds was studied.

It was found that the extraction of REE(III) from weakly acidic chloride solutions into an organic phase containing bis-carbamoylmethylphosphine oxides increases significantly in the presence of picrolonic acid. The stoichiometry of the extracted complexes was determined, the effect of the aqueous phase composition, the nature of the organic solvent and the structure of bis-CMPO on the efficiency of metal ion extraction into the organic phase was considered. The use of picrolonic acid as a chelating component of the extraction mixture leads to a significantly greater increase in the extraction of REE(III) compared to 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone.