Na+/K+ Ratio in Blood Serum as a Criterion of Human Functional State
- 作者: Natochin Y.V.1
-
隶属关系:
- Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS
- 期: 卷 50, 编号 4 (2024)
- 页面: 137-143
- 栏目: Articles
- URL: https://ruspoj.com/0131-1646/article/view/664112
- DOI: https://doi.org/10.31857/S0131164624040111
- EDN: https://elibrary.ru/BSPNVM
- ID: 664112
如何引用文章
详细
The article discusses the physiological significance of the Na+/K+ ratio in blood serum as a criterion of a person’s functional state. Normally, in an adult, the ratio is 32.2 ± 0.5, it increases in a healthy person under the influence of extreme factors (space flight (cosmonauts, astronauts), long-term strict bedrest, etc.), with Covid-19 disease, and some orphan diseases in children. The issue of Na+/K+ in blood serum is being discussed, but not between the K+-rich cell and the Na+-dominated extracellular environment. The Na+/K+ ratio in blood serum is considered as an important parameter of a person’s physiological state and, depending on the numerical value, as an indicator of the functional state from normal to overload, severe complications to the prognosis of death.
全文:

作者简介
Yu. Natochin
Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS
编辑信件的主要联系方式.
Email: natochin1@mail.ru
俄罗斯联邦, St. Petersburg
参考
- Tietz N.W. Clinical Guide to Laboratory Tests. Philadelphia: Saunders Company, 1995. 1096 p.
- Marina A.S., Natochin Yu.V. [Blood and urine analysis in clinical diagnostics // Manuel of Pediatrician]. St. Petersburg: SpetsLit, 2016. 159 p.
- Guyton A.C., Hall J.E. Textbook of Medical physiology. Philadelphia: Elsevier Inc., Saunders, 2006. 1152 p.
- Barcroft J. Features in the architecture of Physiological function. Cambridge: Cambridge University Press, 1934. 359 p.
- Orbeli L.A. [Physiology of the kidneys / Selected works]. Moscow-Leningrad: USSR Academy of Sciences, 1966. V. 4. P. 85.
- Natochin Yu.V. [Homeostasis] // Advances in Physiological Sciences. 2017. V. 48. № 4. P. 3.
- Natochin Yu.V., Ryabov S.I., Kayukov I.G. et al. Parameters of water-salt homeostasis and their variability // Human Physiology. 1980. V. 6. № 4. P. 647.
- Natochin Yu.V., Kuznetsova A.A., Nistarova A.V. [The blood serum Na+/K+ ratio in orphan diseases] // Pathol. Physiol. Exp. Ther. 2021. V. 65. № 3. P. 34.
- Natochin Yu.V., Chernyshev O.B. [Electrolyte concentration in blood serum as prognostic of severe course COVID-19] // Nephrology. 2022. V. 26. № 1. P. 27.
- [Fundamental and medical physiology: A textbook for students of higher educational institutions: in 3 volumes] / Ed. Kamkin A.G. Moscow: De’Libri, 2020. V. 3. 456 p.
- Cannon W.B. Organization for physiological homeostasis // Physiol. Rev. 1929. V. 9. № 3. P. 399.
- Fijorek K., Püsküllüoğlu M., Tomaszewska D. et al. Serum potassium, sodium and calcium levels in healthy individuals – literature review and data analysis // Folia Med. Cracov. 2014. V. 54. № 1. P. 53.
- Natochin Ya.V., Golosova D.V., Kayukov I.G. Blood serum potassium and sodium concentration constants: search for regulatory factors // Human Physiology. 2018. V. 44. № 4. P. 418.
- Grigoriev A.I., Kozyrevskaya G.I., Natochin Yu.V. et al. [Metabolic and endocrine processes / Space flights on Soyuz spacecraft. Biomedical research]. Moscow: Nauka, 1976. P. 266.
- Leach Huntoon C.S., Grigoriev A.I., Natochin Yu.V. San Diego: American Astronautical Society Diego, 1998. 219 p.
- Balbotkina E.V., Ballyuzek M.F., Volovnikova V.A. et al. [Ion-regulating and water-excreting functions of the kidneys in type 2 diabetes mellitus] // Diabetes Mellitus. 2016. V. 19. № 1. P. 64.
- Orbeli L.A. [Main tasks and methods of evolutionary physiology // Selected works]. Moscow-Leningrad: USSR Academy of Sciences, 1961. V. 1. P. 59.
- Natochin Yu.V., Chernigovskaya T.V. Evolutionary physiology: history, principles // Comp. Biochem. Physiol. 1997. V. 118. № 1. P. 63.
- Natochin Y.V. Evolutionary Physiology // J. Evol. Biochem. Physiol. 2017. V. 53. № 2. P. 156.
- Park S., Baek S.H., Lee S.W. et al. Elevated baseline potassium level within reference range is associated with worse clinical outcomes in hospitalised patients // Sci. Rep. 2017. V. 7. № 1. P. 2402.
补充文件
