Mechanism of effect of the zinc and lead ions on state of the oxidation processes in liposomes from lecithin
- 作者: Mashukova A.V.1, Dubovik A.S.1,2, Shvydkiy V.O.1, Shishkina L.N.1
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隶属关系:
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Nesmeyanov Institute of Organoelement compounds, Russian Academy of Sciences
- 期: 卷 44, 编号 3 (2025)
- 页面: 97-105
- 栏目: Химическая физика экологических процессов
- URL: https://ruspoj.com/0207-401X/article/view/679473
- DOI: https://doi.org/10.31857/S0207401X25030108
- ID: 679473
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详细
The influence of divalent zinc and lead ions in a wide range of concentrations on the ability of soy lecithin to spontaneous aggregation in water medium, the zeta potential of he formed liposomes, the ability of metal ions to interact with membranes and their participation in the processes of the lipid peroxidation were studied using the method of dynamic light scattering and mathematical processing of UV-spectra of lecithin and its mixtures with metal ions. It has been shown that the scale and direction of the impact of zinc and lead ions corresponds to their biological activity when entering the body. The data obtained and the analysis of the literature allow us to conclude that the effect of zinc ions at high concentrations on the structural state of membranes and their electrophoretic properties and a significant change in the parameters of the lipid peroxidation regulation system in biological objects in the presence of lead ions, even at low doses, are the basis of their toxicity for biological objects.
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作者简介
A. Mashukova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: shishkina@sky.chph.ras.ru
俄罗斯联邦, Moscow
A. Dubovik
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Nesmeyanov Institute of Organoelement compounds, Russian Academy of Sciences
Email: shishkina@sky.chph.ras.ru
俄罗斯联邦, Moscow; Moscow
V. Shvydkiy
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: shishkina@sky.chph.ras.ru
俄罗斯联邦, Moscow
L. Shishkina
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: shishkina@sky.chph.ras.ru
俄罗斯联邦, Moscow
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