Еffect of light spectrum on elastic-mechanical properties of sclera and myopia development

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Abstract

The paper presents the results of a study of spectrum-induced myopia using a model of quail maturation. Using acoustic microscopy methods in the native state, the geometric dimensions of the structural elements of the eye involved in focusing the optical system were determined, and the patterns of their changes as the body grew and during emmetropization were identified. Particular emphasis was placed on the composition, structure and mechanical properties of the sclera, as the main supporting tissue of the eye, responsible for its shape and size.

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About the authors

N. N. Trofimova

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

Author for correspondence.
Email: ntrofimova@mail.ru
Russian Federation, Moscow

E. A. Khramtsova

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

Email: ntrofimova@mail.ru
Russian Federation, Moscow

Yu. S. Petronyuk

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

Email: ntrofimova@mail.ru
Russian Federation, Moscow

K. G. Antipova

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

Email: ntrofimova@mail.ru
Russian Federation, Moscow

A. E. Krupnin

NRC “Kurchatov Institute”

Email: ntrofimova@mail.ru
Russian Federation, Moscow

A. V. Ratnovskaya

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

Email: ntrofimova@mail.ru
Russian Federation, Moscow

V. V. Sokolova

Emanuel Institute of Biochemical Physics, Russian Academy of Sciences

Email: ntrofimova@mail.ru
Russian Federation, Moscow

E. I. Mednikova

Institute of Biomedical Problems, Russian Academy of Sciences

Email: ntrofimova@mail.ru
Russian Federation, Moscow

T. S. Guryeva

Institute of Biomedical Problems, Russian Academy of Sciences

Email: ntrofimova@mail.ru
Russian Federation, Moscow

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Supplementary files

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2. Fig. 1. Spectra of the used lamps: yellow (1) and blue (2) with maxima at λmax = 560 and blue – λmax = 450 nm, respectively.

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3. Fig. 2. Acoustic images of the quail eye obtained by ultrasound microscopy: 1 – anteroposterior axis, 2 – cornea, 3 – anterior chamber, 4 – lens, 5 – chorioretinal layer, 6 – sclera. Scale bar – 1 mm.

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4. Fig. 3. Structural changes in the quail eye, obtained by ultrasound microscopy in the period of 10–45 days of development. White columns correspond to the group of physiological yellow illumination, gray ones – blue.

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5. Fig. 4. Deformation curves of the quail sclera on the 10th (1), 25th (2) and 45th day (3) of development under blue (a) and yellow (b) illumination.

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6. Fig. 5. Optical images of the sclera of a quail on the 45th day of development under blue (a) and yellow (b) illumination.

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