Synthesis and nucleophilic properties of 1-(2-methoxyethyl) and 1-(2-phenoxyethyl)-3,3-dialkyl-3,4-dihydroisoquinolines

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The Ritter reaction of dialkyl benzyl carbinols with 3-methoxy- and 3-phenoxypropanenitriles afforded the corresponding 1-(2-methoxyethyl)- and 1-(2-phenoxyethyl)-3,3-dialkyl-3,4-dihydroisoquinolines. Likewise, benzo[f]isoquinoline derivatives were synthesized from 2-methyl-3-(naphthalen-1-yl)propan-2-ol. The obtained compounds were shown to have the imine structure, but they exhibited enamine properties. In particular, their reactions with oxalyl chloride resulted in pyrrole annulation.

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作者简介

A. Mikhailovskii

Perm State Pharmaceutical Academy

编辑信件的主要联系方式.
Email: neorghim@pfa.ru
ORCID iD: 0000-0002-5104-4877
俄罗斯联邦, ul. Polevaya, 2, Perm, 614990

A. Yusov

Perm State Pharmaceutical Academy

Email: neorghim@pfa.ru
ORCID iD: 0000-0003-4059-2613
俄罗斯联邦, ul. Polevaya, 2, Perm, 614990

N. Pershina

Perm State Pharmaceutical Academy

Email: neorghim@pfa.ru
ORCID iD: 0000-0002-1422-2902
俄罗斯联邦, ul. Polevaya, 2, Perm, 614990

参考

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