Reaction of 4-Hydroxyspiro[pyrrole-2,3′-pyrrole] and 4′-Hydroxyspiro[imidazole-5,2′-pyrrole] Derivatives with Dicyclohexylcarbodiimide

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Abstract

The reaction of substituted 4-hydroxyspiro[pyrrole-2,3′-pyrrole] and 4′-hydroxyspiro[imidazole-5,2′-pyrrole] with dicyclohexylcarbodiimide leads to the corresponding derivatives of 4-ureidospiro[pyrrole-2,3′-pyrrole] and 4′-ureidospiro[imidazole-5,2′-pyrrole]. The thermal decomposition of the obtained ureidospirobisheterocycles proceeds nonselectively.

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About the authors

A. N. Maslivets

Perm State University

Email: koh2@psu.ru
ORCID iD: 0000-0001-7148-4450
Russian Federation, ul. Bukireva, 15, Perm, 614990

E. A. Lystsova

Perm State University

Email: koh2@psu.ru
ORCID iD: 0000-0003-0453-0589
Russian Federation, ul. Bukireva, 15, Perm, 614990

E. E. Khramtsova

Perm State University

Author for correspondence.
Email: koh2@psu.ru
ORCID iD: 0000-0002-5851-3082
Russian Federation, ul. Bukireva, 15, Perm, 614990

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Supplementary files

Supplementary Files
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2. Fig. 1. Naturally occurring pyrrol-2-one derivatives

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3. Fig. 2. Some 3-hydroxy-substituted 1,5-dihydro-2H-pyrrol-2-ones exhibiting biological activity

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4. Fig. 3. Antiproliferative activity of some 3-hydroxy- and 3-amino-1,5-dihydro-2H-pyrrol-2-ones [12]

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5. Fig. 4. General view of the molecule of compound 9a according to X-ray diffraction data in thermal ellipsoids of 30% probability

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6. Scheme 3

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7. Fig. 4. Characteristic signals of compounds 7a,b, 9a,b and 3, 5 [17] according to IR spectra

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8. Fig. 5. Characteristic signals of compounds 7a,b, 9a,b and 3, 5 [17] according to NMR ¹H spectra

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9. Fig. 6. Characteristic signals of compounds 7a,b, 9a,b and 3, 5 [17] according to NMR ¹³C spectra

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