Synthesis, Antiarrhythmic and Anticonvulsant Activity of the Aminoamides and Aminoesters on the Base of 1-(4-Fluorophenyl)- and 1-(3-(Trifluoromethyl)phenyl)cyclopentanecarboxylic Acides

Zh. S. Arustamyan; Арустамян Жасмина Cаркисовна; R. E. Margaryan; Маркарян Рузанна Эдуардовна; A. A. Aghekyan; Агекян Aся Aгековна; G. S. Mkrtchyan; Мкртчян Гоар Сааковна; R. E. Muradyan; Мурадян Рафаэль Егиазарович; M. S. Grigoryan; Григорян Марине Сениковна; H. A. Panosyan; Паносян Генрих Агавардович; G. G. Mkryan; Мкрян Геворг Гургенович

doi:10.31857/S0514749224080069

Synthesis, Antiarrhythmic and Anticonvulsant Activity of the Aminoamides and Aminoesters on the Base of 1-(4-Fluorophenyl)- and 1-(3-(Trifluoromethyl)phenyl)cyclopentanecarboxylic Acides

作者: Arustamyan Z.S.¹, Margaryan R.E.¹, Aghekyan A.A.¹, Mkrtchyan G.S.¹, Muradyan R.E.¹, Grigoryan M.S.¹, Panosyan H.A.¹, Mkryan G.G.¹
隶属关系:
1. Scientific Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
期: 卷 60, 编号 8 (2024)
页面: 44-52
栏目: Articles
URL: https://ruspoj.com/0514-7492/article/view/676685
DOI: https://doi.org/10.31857/S0514749224080069
EDN: https://elibrary.ru/RAFTGV
ID: 676685

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Alkylation of 2-(4-fluorophenyl)- and 2-(3-(trifluoromethyl)phenyl)acetonitrile with 1,4-dibrombutane gave the nitrile of the substituted phenylcyclopentane-1 carboxylic acids. Alkaline hydrolysis of the latter in ethyleneglycol corresponding acids were obtained, the interaction of acid chlorides of which with N,N-dialkylaminoalkyl- and heterylalkylamines, also with N,N-dialkylaminoalkyl- and heterylalkylalcohols, synthesized new aminoamides and aminoesters derivatives in a series of 1-(4-fluorophenyl)- and 1-(3-(trifluoromethyl)phenyl)cyclopentanecarboxylic acids. The antiarrhythmic activity of synthesized compounds has been investigated.

关键词

1-(4-fluorophenyl)cyclopentanecarboxylic acid, 1-(3-(trifluoromethyl)phenyl) cyclopentanecarbo-xylic acid, dialkylaminoalkylamine, heterylalkylalcohol, aminoamide, aminoester

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