Synthesis, Antiarrhythmic and Anticonvulsant Activity of the Aminoamides and Aminoesters on the Base of 1-(4-Fluorophenyl)- and 1-(3-(Trifluoromethyl)phenyl)cyclopentanecarboxylic Acides
- 作者: Arustamyan Z.S.1, Margaryan R.E.1, Aghekyan A.A.1, Mkrtchyan G.S.1, Muradyan R.E.1, Grigoryan M.S.1, Panosyan H.A.1, Mkryan G.G.1
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隶属关系:
- Scientific Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
- 期: 卷 60, 编号 8 (2024)
- 页面: 44-52
- 栏目: Articles
- URL: https://ruspoj.com/0514-7492/article/view/676685
- DOI: https://doi.org/10.31857/S0514749224080069
- EDN: https://elibrary.ru/RAFTGV
- ID: 676685
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详细
Alkylation of 2-(4-fluorophenyl)- and 2-(3-(trifluoromethyl)phenyl)acetonitrile with 1,4-dibrombutane gave the nitrile of the substituted phenylcyclopentane-1 carboxylic acids. Alkaline hydrolysis of the latter in ethyleneglycol corresponding acids were obtained, the interaction of acid chlorides of which with N,N-dialkylaminoalkyl- and heterylalkylamines, also with N,N-dialkylaminoalkyl- and heterylalkylalcohols, synthesized new aminoamides and aminoesters derivatives in a series of 1-(4-fluorophenyl)- and 1-(3-(trifluoromethyl)phenyl)cyclopentanecarboxylic acids. The antiarrhythmic activity of synthesized compounds has been investigated.
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作者简介
Zh. Arustamyan
Scientific Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: aaghekyan@mail.ru
ORCID iD: 0000-0002-0541-5315
亚美尼亚, Yerevan
R. Margaryan
Scientific Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: aaghekyan@mail.ru
ORCID iD: 0000-0002-5066-0870
亚美尼亚, Yerevan
A. Aghekyan
Scientific Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
编辑信件的主要联系方式.
Email: aaghekyan@mail.ru
ORCID iD: 0000-0001-6151-4951
亚美尼亚, Yerevan
G. Mkrtchyan
Scientific Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: aaghekyan@mail.ru
亚美尼亚, Yerevan
R. Muradyan
Scientific Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: aaghekyan@mail.ru
亚美尼亚, Yerevan
M. Grigoryan
Scientific Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: aaghekyan@mail.ru
ORCID iD: 0000-0002-6705-8536
亚美尼亚, Yerevan
H. Panosyan
Scientific Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: aaghekyan@mail.ru
ORCID iD: 0000-0001-8311-6276
亚美尼亚, Yerevan
G. Mkryan
Scientific Technological Centre of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: aaghekyan@mail.ru
ORCID iD: 0000-0001-9879-9524
亚美尼亚, Yerevan
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