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Synthesis and antioxidant activity furan derivatives containing 1,3,4-oxadiazole ring
- Authors: Aghekyan A.A.1, Panosyan H.A.1, Buniatyan Z.M.1, Muradyan R.E.1, Mkryan G.G.1
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Affiliations:
- The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
- Issue: Vol 60, No 5 (2024)
- Pages: 614-622
- Section: Articles
- URL: https://ruspoj.com/0514-7492/article/view/685340
- DOI: https://doi.org/10.31857/S0514749224050045
- EDN: https://elibrary.ru/RDHUFK
- ID: 685340
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Abstract
N-methylaminoamide derivatives were obtained by the reaction of methyl esters of 5-aminomethyl-substituted furocarboxylic acids with methylamine, and the corresponding amino acids were isolated by hydrolysis. Hydrazides were synthesized by interaction above mention esters with hydrazine hydrate, which were converted via diamide derivatives into biheterocyclic compounds containing furan and 1,3,4-oxadiazole rings. The target biheterocycles were also synthesized by the reaction of hydrazides with acid chlorides in the presence of phosphorus oxychloride in one stage without isolating diamides.
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About the authors
A. A. Aghekyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Author for correspondence.
Email: aaghekyan@mail.ru
ORCID iD: 0000-0001-6151-4951
Armenia, prosp. Azatutyana, 26, Yerevan, 0014
H. A. Panosyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID iD: 0000-0001-8311-6276
Armenia, prosp. Azatutyana, 26, Yerevan, 0014
Zh. M. Buniatyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID iD: 0000-0002-3152-3176
Armenia, prosp. Azatutyana, 26, Yerevan, 0014
R. E. Muradyan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID iD: 0000-0002-4110-9454
Armenia, prosp. Azatutyana, 26, Yerevan, 0014
G. G. Mkryan
The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Email: aaghekyan@mail.ru
ORCID iD: 0000-0001-9879-9524
Armenia, prosp. Azatutyana, 26, Yerevan, 0014
References
- Lukevits É., Demicheva L. Chem. Heterocycl. Compd. 1993, 29, 243–267. doi: 10.1007/BF00531499
- Loğoğlu E., Yilmaz M., Katircioğlu H., Yakut M., Mercan S. Med. Chem. Res. 2010, 19, 490–497. doi: 10.1007/s00044-009-9206-8
- Dai B., Ma X., Tang Y., Xu L., Chen X., Lu S., Wang G., Liu Y. Bioorg. Med. Chem. 2021, 29, 115891. doi: 10.1016/j.bmc.2020.115891
- Alizadeh M., Jalal M., Hamed K., Saber A., Kheirouri S., Pourteymour Fard Tabrizi F., Kamari N. J. Inflamm. Res. 2020, 13, 451–463. doi: 10.2147/JIR.S262132
- Tomasic T., Masic L. Curr. Med. Chem., 2009, 16, 1596–1629. doi: 10.2174/092986709788186200
- Игидов С.Н., Турышев А.Ю., Махмудова Р.Р., Шипиловских Д.А., Игидов Н.М., Шипиловских С.А. ЖOX, 2022, 92,1378–1386. [Igidov S.N., Turyshev A.Yu., Makhmudov R.R., Shipilovskikh D.A., Igidov N.M, Shipilovskikh S.A. Russ. J. Gen. Chem. 2022, 92, 1629–1636.] doi: 10.1134/S1070363222090067
- Yusuf Sicak Med. Chem. Res. 2021, 30, 1557–1568. doi: 10.1007/s00044-021-02756-z
- Karabelyov V., Kondeva-Burdina M., Angelova V.T. Bioorg. Med. Chem. 2021, 29, 115888. doi: 10.1016/j.bmc.2020.115888
- Rashid M., Husain A., Mishra R. Eur. J. Med. Chem. 2012, 54, 855–866. doi: 10.1016/j.ejmech.2012.04.027
- Арутюнян А.В., Дубинина Е.Е., Зыбина Н.А. Методы оценки свободнорадикального окисления и антиоксидантной системы организма. СПб, ИКФ «Фолиант», 2000, 90–94.
- Владимиров Ю.А., Азизова О.А., Даев А.И., Козлов А.В. Свободные радикалы в живых системах. М: ВИНИТИ, 1991, 29, 126–130.
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