Synthesis of hexa-substituted benzene derivative based on 4-pyridinecarboxaldehyde and malononitrile

I. G. Mamedov; Мамедов И. Г.; F. N. Naghiyev; Нагиев Ф. Н.; I. A. Yakushev; Якушев И. А.; V. N. Khrustalev; Хрусталев В. Н.

doi:10.31857/S0514749225030113

Synthesis of hexa-substituted benzene derivative based on 4-pyridinecarboxaldehyde and malononitrile

Authors: Mamedov I.G.¹, Naghiyev F.N.¹, Yakushev I.A.², Khrustalev V.N.³^,4
Affiliations:
1. Baku State University
2. Kurnakov Institute of General and Inorganic Chemistry of RAS
3. Peoples’ Friendship University of Russia (RUDN University)
4. dZelinsky Institute of Organic Chemistry RAS
Issue: Vol 61, No 3 (2025)
Pages: 308-312
Section: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
URL: https://ruspoj.com/0514-7492/article/view/687712
DOI: https://doi.org/10.31857/S0514749225030113
EDN: https://elibrary.ru/EUFMTK
ID: 687712

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Abstract
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Abstract

The present work reports the synthesis of a new compound 2-amino-4,6-di(pyridin-4-yl)benzene-1.3.5-tricarbonitrile as a result of the reaction of two moles of 2-(pyridin-4-ylmethylene)malononitrile with one mole of malononitrile in the presence of methylpiperazine as a catalyst. The structure of the obtained product was confirmed by NMR and X-ray. A plausible reaction mechanism is presented.

Keywords

piperazine, benzene, pyridine, malonodinitrile, carbonitrile

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About the authors

I. G. Mamedov

Baku State University

Author for correspondence.
Email: bsu.nmrlab@gmail.com
ORCID iD: 0000-0002-5757-9899

химический факультет

Azerbaijan, ul. Z. Khalilova, 23, Baku, Az-1148

F. N. Naghiyev

Baku State University

Email: bsu.nmrlab@gmail.com
ORCID iD: 0009-0003-9325-1756

химический факультет

Azerbaijan, ul. Z. Khalilova, 23, Baku, Az-1148

I. A. Yakushev

Kurnakov Institute of General and Inorganic Chemistry of RAS

Email: bsu.nmrlab@gmail.com
Russian Federation, Leninsky prosp., 31, Moscow, 119071

V. N. Khrustalev

Peoples’ Friendship University of Russia (RUDN University); dZelinsky Institute of Organic Chemistry RAS

Email: bsu.nmrlab@gmail.com
ORCID iD: 0000-0001-8806-2975
Russian Federation, ul. Miklukho-Maklaya, 6, Moscow, 117198; Leninsky prosp., 47, Moscow, 119991

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