N-arylation of 1,2,4- and 1,3,4-oxadiazolones under the conditions of activitated aromatic nucleophilic substitution

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

The possibilities of N -arylation of 1,2,4-oxadiazol-5(4 Н )-ones and 1,3,4-oxadiazol-2(3 Н )-ones with various electron-deficient chloro- and fluorine-substituted nitroarenes under the conditions of classical activated nucleophilic substitution were studied. A significant difference was shown in the reactivity of 1,2,4- and 1,3,4-oxadiazolones in N -arylation reactions. Methods for the synthesis of N-nitroaryl derivatives have been developed.1,2,4- and 1,3,4-oxadiazolones, providing yields of target products with sufficient purity and good yields at the level of 65-96%.

Авторлар туралы

A. Konstantinova

Pharmaceutical Technology Transfer Center, Ushinsky Yaroslavl State Pedagogical University;Russian State University named after A.N. Kosygin (Technology. Design. Art)

Email: a.konstantinova@yspu.org

A. Shetnev

Pharmaceutical Technology Transfer Center, Ushinsky Yaroslavl State Pedagogical University

Email: a.shetnev@list.ru

A. Volobueva

Saint Petersburg Pasteur Institute

M. Korsakov

Russian State University named after A.N. Kosygin (Technology. Design. Art)

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