Alkylation of Ethyl 2-Aryl-1-hydroxy-4-methyl-1 Н -imidazole-5-carboxylates with Benzyl Halides

Polina A. Nikitina; Никитина Полина Андреевна; Irina A. Oskina; Оськина Ирина Александровна; Elena B. Nikolaenkova; Николаенкова Елена Борисовна; Ekaterina A. Kulikova; Куликова Екатерина Андреевна; Vladimir S. Miroshnikov; Мирошников Владимир Сергеевич; Valery P. Perevalov; Перевалов Валерий Павлович; Alexey Ya. Tikhonov; Тихонов Алексей Яковлевич

doi:10.31857/S0514749225040144

Alkylation of Ethyl 2-Aryl-1-hydroxy-4-methyl-1Н-imidazole-5-carboxylates with Benzyl Halides

Авторлар: Nikitina P.A.¹, Oskina I.A.², Nikolaenkova E.B.², Kulikova E.A.¹, Miroshnikov V.S.¹, Perevalov V.P.¹, Tikhonov A.Y.²
Мекемелер:
1. Mendeleev University of Chemical Technology of Russia
2. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the RAS
Шығарылым: Том 61, № 4 (2025)
Беттер: 475-483
Бөлім: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
URL: https://ruspoj.com/0514-7492/article/view/689699
DOI: https://doi.org/10.31857/S0514749225040144
EDN: https://elibrary.ru/SEOHNP
ID: 689699

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат
Рұқсат жабық

Рұқсат берілді
Рұқсат жабық

Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация
Толық мәтін
Авторлар туралы
Әдебиет тізімі
Қосымша файлдар
Статистика

Аннотация

Alkylation of ethyl 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylates with substituted benzyl halides led to the selective formation of O-alkoxy derivatives. Products of N-alkylation (1-alkylimidazole 3-oxides) could be obtained by condensation reaction from acyclic starting compounds. If a 2-hydroxyphenyl moiety was present in position 2 of imidazole ring, then monoalkylation proceeded selectively at hydroxy group of the nitrogen atom of heterocycle.

Негізгі сөздер

alkylation, 1-hydroxyimidazoles, 1-benzylimidazoles, imidazole 3-oxides, benzyl halides

Толық мәтін

Авторлар туралы

Polina Nikitina

Mendeleev University of Chemical Technology of Russia

Хат алмасуға жауапты Автор.
Email: polinandrevna@yandex.ru
ORCID iD: 0000-0003-1542-5565
Ресей, 9, Miusskaya Sqr., Moscow, 125047

Irina Oskina

Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the RAS

Email: polinandrevna@yandex.ru
ORCID iD: 0000-0001-5788-0182
Ресей, 9, Ac. Lavrentyev Ave., Novosibirsk, 630090

Elena Nikolaenkova

Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the RAS

Email: polinandrevna@yandex.ru
ORCID iD: 0009-0000-5034-8513
Ресей, 9, Ac. Lavrentyev Ave., Novosibirsk, 630090

Ekaterina Kulikova

Mendeleev University of Chemical Technology of Russia

Email: polinandrevna@yandex.ru
ORCID iD: 0009-0009-2311-395X
Ресей, 9, Miusskaya Sqr., Moscow, 125047

Vladimir Miroshnikov

Mendeleev University of Chemical Technology of Russia

Email: polinandrevna@yandex.ru
ORCID iD: 0000-0003-3815-7479
Ресей, 9, Miusskaya Sqr., Moscow, 125047

Valery Perevalov

Mendeleev University of Chemical Technology of Russia

Email: polinandrevna@yandex.ru
ORCID iD: 0000-0002-3980-6496
Ресей, 9, Miusskaya Sqr., Moscow, 125047

Alexey Tikhonov

Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the RAS

Email: polinandrevna@yandex.ru
ORCID iD: 0000-0002-6391-4366
Ресей, 9, Ac. Lavrentyev Ave., Novosibirsk, 630090

Әдебиет тізімі

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