COMPARATIVE TOXICITY OF CERTAIN ALCOHOLS AND ALCOHOL-BASED SKIN ANTISEPTICS

M. V. Bidevkina; Бидевкина М. В.; O. V. Baklanova; Бакланова О. В.; T. Z. Rysina; Рысина Т. З.; I. A. Suetina; Суетина И. А.; O. A. Lopatina; Лопатина О. А.; T. N. Potapova; Потапова Т. Н.; M. V. Mezentseva; Мезенцева М. В.; A. V. Limantsev; Лиманцев А. В.; L. I. Russu; Руссу Л. И.; Zh. P. Alekseeva; Алексеева Ж. П.

doi:10.36946/0869-7922-2016-2-19-24

COMPARATIVE TOXICITY OF CERTAIN ALCOHOLS AND ALCOHOL-BASED SKIN ANTISEPTICS

Authors: Bidevkina M.V.¹, Baklanova O.V.², Rysina T.Z.¹, Suetina I.A.², Lopatina O.A.², Potapova T.N.¹, Mezentseva M.V.², Limantsev A.V.¹, Russu L.I.², Alekseeva Z.P.¹
Affiliations:
1. Scientific Research Disinfectology Institute, Rospotrebnadzor
2. D.I. Ivanovsky Institute of Virology, N.F.Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of Russia
Issue: No 2 (2016)
Pages: 19-24
Section: Articles
Published: 28.04.2016
URL: https://ruspoj.com/0869-7922/article/view/640942
DOI: https://doi.org/10.36946/0869-7922-2016-2-19-24
ID: 640942

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Abstract

The cytotoxic action of skin antiseptics based on ethyl, propyl and isopropyl alcohols were investigated into the culture of human embryonic fibroblast cells using MTT-test and xCELLigence system for real-time analysis into the bull spermatozoa with registering toxicity index. The dependence of the cytotoxicity degree on the chemical composition of a preparation was established. The investigation of antiseptics skin-resorptive action mechanisms in weanling rats has shown that prepubertal females are more sensitive to the effect of alcohols compared to males. The use of skin antiseptics based on ethyl and isopropyl alcohols is recommended for hygienic treatment of children’s hands.

Keywords

skin antiseptics, alcohols, cytotoxic action, cell culture, laboratory animals

References

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COMPARATIVE TOXICITY OF CERTAIN ALCOHOLS AND ALCOHOL-BASED SKIN ANTISEPTICS

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