BLOOD ESTRERASE PROFILE IN MICE AT ACUTE INTOXICATION BY 2-(О-CRESYL)-4Н-1,3,2- BENZODIOXAPHOSPHORIN-2-OXIDE

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

The influence of 2-(o-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP) on the blood esterase profile in mice was studied at different doses an hour and 24 h after its subcutaneous administration to animals. It is established that CBDP is not a specific carboxyl esterase inhibitor in mice blood serum as it equally inhibits blood butyrylcholinesterase as well. CBDP is a low effective acetylcholinesterase inhibitor in mice blood serum and does not pose an expressed effect in respect to acetylcholinesterase in erythrocytes membranes, however in high doses it is able to lower their amount.

About the authors

D. S. Prokofieva

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

V. I. Shmurak

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: noemail@neicon.ru
Russian Federation

A. E. Krivoshein

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: noemail@neicon.ru
Russian Federation

E. A. Bodryakova

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: noemail@neicon.ru
Russian Federation

N. G. Voitenko

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: noemail@neicon.ru
Russian Federation

References

  1. Bahar F.G., Imai T. Aspirin Hydrolysis in Human and Experimental Animal Plasma and the Effect of Metal Cations on Hydrolase Activities. Drug MetabDispos. 2013; 41:1450–1456.
  2. Clement. J.G.Importance of aliesterase as a detoxification mechanism for soman (piinacolylmethylphosphonofluoridate) in mice. Biochemical Pharmacology. 1984; 33 (23): 3807-3811.
  3. Maxwell D.M., Brecht K.M., O’Neill B.L. The effect of carboxylesterase inhibition on interspecies differences in soman toxicity. Toxico. Lett. 1987;39(1):35-42.
  4. Garrett T.L., Rapp C.M., Grubbs R.D., Schlager J.J., Lucot J.B. A murine model for sarin exposure using the carboxylesterase inhibitor CBDP. NeuroToxicology. 2010; 31: 502–508.
  5. Yang Z.P., Dettbarn W.D.Prevention of tolerance to the organophosphorus anticholinesterase paraoxon with carboxylesterase inhibitors. BiochemPharmacol. 1998; 55(9):1419- 1426.
  6. Clement J.G., Erhardt N. Serum carboxylesterase activity in various strains of rats: sensitivity to inhibition by CBDP (2-/o-cresyl/4H:1:3:2- benzodioxaphosphorin-2-oxide). Arch. Toxicol. 1990; 64(5): 414– 416.
  7. Nomeir A.A., Abou-Donia M.B. Studies on the metabolism of neurotoxic tri-ocresyl phosphate. Toxicology. 1986; 38: 1-13.
  8. Ellman G.L., Courtney K.D., Andres V.Jr., Feather-Stone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 1961. V.7.: 88-95.
  9. Курдюков И.Д., Дубровский Я.А., Бабаков В.Н., Гончаров Н.В. Исследование полиморфизмов параоксоназы-1 у населения Кировской области. Токсикологический Вестник. 2012. №4, С. 13-18.
  10. CarlettiE., SchopferL.M., ColletierJ.P., FromentM.T., NachonF., WeikM., LockridgeO., MassonP. ReactionofCresylSaligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-ray Structure Analysis. Chem. Res. Toxicol. 2011; 24: 797 – 808.
  11. Прокофьева Д.С., Кривошеин А.Е., Шмурак В.И., Бодрякова Е.А., Войтенко Н.Г. Определение оптимальной дозы 2-(о-крезил)-4Н-1,3,2-бензодиоксофосфорин-2-оксида для селективного ингибирования карбоксилэстераз сыворотки крови крыс invivo. Ученые записки Орловского государственного университета. 2014;7(63): 255-256.
  12. Chambers J.P., Hartgraves S.L., Murphy M.R., Wayner M.J., Kumar N., Valdes J.J.Effects of three reputed carboxylesterase inhibitors upon rat serum esterase activity. Neurosci.Biobehav.Rev. 1991; 15(1):85-88.
  13. Shapira S., Kadar T., Cohen G., Chapman S., Raveh L. Effects of CBDP and MEPQ on the toxicity and distribution of [3H]-soman in mice. Arch Toxicol. 1990;64(8):663-668.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2016 Prokofieva D.S., Shmurak V.I., Krivoshein A.E., Bodryakova E.A., Voitenko N.G.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 81728 от 11 декабря 2013.