EXPERIMENTAL DATA AND METHODOLOGICAL CONSIDERSATIONS FOR JUSTIFICATION OF IRON OXIDE NANOPARTICLES MAXIMUM ALLOWABLE CONCENTRATION IN OCCUPSATIONAL AIR

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Abstract

Airborne Fe2O3 nanoparticles (NPs) with an average diameter of 14 ± 4 nm, obtained by sparking iron rods of 99.9% purity were fed to a “nose only” type exposition installation for 4 hours 5 times a week over 10 months at an average concentration of 1.14 ± 0.01 mg / m3. A very low accumulation of Fe2O3-NPs in the lung tissue gradually increasing over time was found out. As judged by the almost normal histology of lung and lung-associated lymph nodes and low content of hydroxyproline in the lungs, the intensity of the developing pneumoconiosis was not important. Functional and biochemical indices of the body’s condition mostly remained normal, but some of them made consider tested NP concentration as threshold value in the chronic systemic toxicity. In accordance with general principles of setting MAC for occupational air, it was suggested to consider justified a concentration of 0.4 mg / m3, as MAC value for iron-oxide NPs.

About the authors

M. P. Sutunkova

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Rospotrebnadzor

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

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