EFFECTIVENESS PROGNOSTICATION OF A COMBINED ANALGESIC FORMULATION DEPENDING ON QUANTITATIVE COMPOSITION OF ITS COMPONENTS

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Abstract

In experiments on rats, analgesic activity of fentanyl opioid receptor agonist and central 2-adrenomimetic dexmedetomidine as well as the character of their interaction at a combined administration were studied. Meaneffective anesthetic doses of the drugs in heat radiant tail flick test were 54.5 and 22.5 μg/kg correspondingly. Using izobolographic analysis, it was shown that for a combination with equal parts or with a greater part of fentanyl, the type of drug interaction can be characterized as potentiation. A model of prognostication of probability values of the analgesic effect development in relation to doses of combination components was elaborated and experimentally tested.

About the authors

N. G. Vengerovich

State Research and Test Institute of Military Medicine, RF Ministry of Defense

Author for correspondence.
Email: noemail@neicon.ru
195043, Saint Petersburg Russian Federation

M. A. Yudin

State Research and Test Institute of Military Medicine, RF Ministry of Defense

Email: noemail@neicon.ru
195043, Saint Petersburg Russian Federation

A. S. Nikiforov

State Research and Test Institute of Military Medicine, RF Ministry of Defense

Email: noemail@neicon.ru
195043, Saint Petersburg Russian Federation

G. S. Sagalov

S.M. Kirov Medical Military Academy, RF Ministry of Defense

Email: noemail@neicon.ru
194044, Saint Petersburg Russian Federation

M. S. Vakhviyainen

Innovative pharmaceutical company “Silver Pharm” Ltd

Email: noemail@neicon.ru
195279, Saint Petersburg Russian Federation

A. A. Kuzmin

State Research and Test Institute of Military Medicine, RF Ministry of Defense

Email: noemail@neicon.ru
195043, Saint Petersburg Russian Federation

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Copyright (c) 2016 Vengerovich N.G., Yudin M.A., Nikiforov A.S., Sagalov G.S., Vakhviyainen M.S., Kuzmin A.A.


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