CONCERNING COORDINATION BETWEEN THE GENERALLY ACCEPTED PRACTICE OF ASSESSING HEALTH RISKS DUE TO MULTI-METALLIC EXPOSURES AND THE THEORY OF COMBINED TOXICITY

I. A. Minigalieva; Минигалиева И. А.; B. A. Katsnelson; Кацнельсон Б. А.; V. B. Gurvich; Гурвич В. Б.; L. I. Privalova; Привалова Л. И.; V. G. Panov; Панов В. Г.; A. N. Varaksin; Вараксин А. Н.; M. P. Sutunkova; Сутункова М. П.

doi:10.36946/0869-7922-2017-4-13-18

CONCERNING COORDINATION BETWEEN THE GENERALLY ACCEPTED PRACTICE OF ASSESSING HEALTH RISKS DUE TO MULTI-METALLIC EXPOSURES AND THE THEORY OF COMBINED TOXICITY

Authors: Minigalieva I.A.¹, Katsnelson B.A.¹, Gurvich V.B.¹, Privalova L.I.¹, Panov V.G.², Varaksin A.N.², Sutunkova M.P.¹
Affiliations:
1. The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of Rospotrebnadzor
2. Institute of Industrial Ecology, the Ural Branch of the Russian Academy of Sciences
Issue: No 4 (2017)
Pages: 13-18
Section: Articles
Published: 28.08.2017
URL: https://ruspoj.com/0869-7922/article/view/641010
DOI: https://doi.org/10.36946/0869-7922-2017-4-13-18
ID: 641010

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Abstract

Assessment of cumulative health risks associated with the widely observed combined effects of two or more metals and their compounds to the organism has the toxicology of mixtures as its scientific basis although there is no full match between such assessment and this basis though some of the contradictions between them are of a fundamental nature. This state of things may be explained not only by simplifications characteristic of the generally recognized methodology of risk assessment but also by extreme complexity of the theory of combined toxicity, the most essential issues of which are considered by authors on the basis of literary and, mostly, their own previously published data.

Keywords

toxic metals, typology of combined toxicity, mathematical modeling, health risk assessment

References

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CONCERNING COORDINATION BETWEEN THE GENERALLY ACCEPTED PRACTICE OF ASSESSING HEALTH RISKS DUE TO MULTI-METALLIC EXPOSURES AND THE THEORY OF COMBINED TOXICITY

Full Text

Abstract

Keywords

About the authors

I. A. Minigalieva

B. A. Katsnelson

V. B. Gurvich

L. I. Privalova

V. G. Panov

A. N. Varaksin

M. P. Sutunkova

References

Supplementary files