Email this article EFFECT OF KAGOCEL PREPARATION ON THE GENERATIVE FUNCTION OF EXPERIMENTAL ANIMALS AT ITS ADMINISTRATION IN THE INFANTILE PERIOD OF THEIR DEVELOPMENT
- Authors: Borovskaya T.A.1, Poluektova M.E.1, Vychuzhanina A.V.1, Mashanova V.A.1, Shchemerova Y.A.1
-
Affiliations:
- Structural unit «Scientific Research Institute of Pharmacology and Regenerative» Medicine named after E.D. Goldberg», Federal State Budget Scientific Institution «Tomsk National Research Medical Center» of the Russian Academy of Sciences
- Issue: No 3 (2017)
- Pages: 42-49
- Section: Articles
- Published: 28.06.2017
- URL: https://ruspoj.com/0869-7922/article/view/641013
- DOI: https://doi.org/10.36946/0869-7922-2017-3-42-49
- ID: 641013
Cite item
Full Text
Abstract
In experimental studies on rats (males, females) at their infantile stage starting from 10 days, a potential delayed toxic effect of the antiviral drug Kagocel on the reproductive system was studied. The drug was administered for 12 days in a therapeutic dose and at a dose 10-fold higher than the therapeutic one. Reproductive safety was estimated after animals reached the reproductive age (2.5 months). It was found out that the drug, when administered in both doses, does not decrease the fertility of animals, does not induce morphological and pathological changes in the sex glands, and does not have toxic effect on the offspring. Obtained data characterize Kagocel as a preparation with a wide reproductive safety profile and show that it can be used in pediatric practice for infants.
About the authors
T. A. Borovskaya
Structural unit «Scientific Research Institute of Pharmacology and Regenerative» Medicine named after E.D. Goldberg», Federal State Budget Scientific Institution «Tomsk National Research Medical Center» of the Russian Academy of Sciences
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
M. E. Poluektova
Structural unit «Scientific Research Institute of Pharmacology and Regenerative» Medicine named after E.D. Goldberg», Federal State Budget Scientific Institution «Tomsk National Research Medical Center» of the Russian Academy of Sciences
Email: noemail@neicon.ru
Russian Federation
A. V. Vychuzhanina
Structural unit «Scientific Research Institute of Pharmacology and Regenerative» Medicine named after E.D. Goldberg», Federal State Budget Scientific Institution «Tomsk National Research Medical Center» of the Russian Academy of Sciences
Email: noemail@neicon.ru
Russian Federation
V. A. Mashanova
Structural unit «Scientific Research Institute of Pharmacology and Regenerative» Medicine named after E.D. Goldberg», Federal State Budget Scientific Institution «Tomsk National Research Medical Center» of the Russian Academy of Sciences
Email: noemail@neicon.ru
Russian Federation
Yu. A. Shchemerova
Structural unit «Scientific Research Institute of Pharmacology and Regenerative» Medicine named after E.D. Goldberg», Federal State Budget Scientific Institution «Tomsk National Research Medical Center» of the Russian Academy of Sciences
Email: noemail@neicon.ru
Russian Federation
References
- Ситников И.Г., Еганян Г.А., Гроппа Л.Г. Лечение ОРВИ и гриппа в рутинной клинической практике: результаты промежуточного анализа неинтервенционного, открытого, проспективного, наблюдательного исследования. // Лечащий врач. 2015; 9:2-7.
- Долгих Т.Н., Минакова Е. Ю., Запарий Н.С. Клинико-иммунологическая оценка эффективности применения Кагоцела при лечении пациентов с рецидивирующей герпетической инфекцией. // Российский журнал кожных болезней. 2010; 1:15-18.
- Лукиных Л.М., Толмачева С.М, Спиридонова С.А. Оценка эффективности комбинированного лечения герпетического стоматита противовирусными препаратами фамвир и кагоцел. // Медицинский альманах. 2012; 5: 223-225.
- Фазылов В.Х., Ситников И.Г., Силина Е.В., Шевченко С.Б., Можина Л.Н., Замятина Л.Л., Еганян Г.А., Гроппа Л.Г., Корсантия Б.М. Лечение ОРВИ и гриппа в рутинной клинической практике (результаты многоцентрового международного наблюдательного исследования FLU-EE). // Терапевтический архив. 2016, Том 88, №11, С. 1-8.
- Peyster A., Wang Y. Genetic toxicity studies of gossypol // Mutat. Res. 1993; 297: 293-312.
- European Food Safety Authority. Scientific opinion. Gossypol as undesirable substance in animal feed. Scientific Opinion of the Panel on Contaminants in the Food Chain (Question No EFSAQ- 2005-222). Adopted on 4 December 2008 // The EFSA Journal. 2008; 908; 1–55.
- An T, Ouyang W., Pan W., Guo D. , Li J, Li L, Chen G, Yang J, Wu S, Tien P. Amino acid derivatives of the (-) enantiomer of gossypol are effective fusion inhibitors of human immunodeficiency virus type 1 / Antiviral Res. , 1986; 1: 48–52.
- Huang J.X., Zhao S.X., Gu Z.P., Zhu Y.Q., Ji R.Y. Studies on the synthesis of gossypol derivatives and their anti-fertility action //Shengzhi Yu Biyun. 1986; 1: 48–52.
- Илябаев К. З., Камаев Ф. Г., Выпова Н. Л., Юлдашев А. М., Ибрагимов Б. Т., Талипов С. А. Синтез, структура и «острая» токсичность несимметричных альдегидных производных госсипола. // Биоорганическая химия. 2010; 3: 423–428.
- Juanjuan Yin. Сhemical modification and biological activity exploration of the natural product-gossypol // A Dissertation for the Degree of Doctor of Philosophy The Graduate School of Clemson University. 2010.
- Рыбалкин С.П., Ковалева Е.В., Гуськова Т.А., Савинова Т.Б. Экспериментальная оценка влияния препарата Кагоцел на генеративную функцию животных. // Токсикологический вестник. 2013; 2: 33-38.
- Дурнев А.Д., Смольникова Н.М, Скосырева А.М., Немова Е.П, и др. Методические рекомендации по изучению репродуктивной токсичности лекарственных средств. В кн.: Руководство по проведению доклинических исследований лекарственных средств. Миронов А.Н. ред. Ч.1. М.: Изд. ФГБУ «НЦЭСМП»; 2013: 80-94.
Supplementary files
