EXPERIMENTAL EVALUATION OF CHRONIC ORAL TOXICITY AND LONG-TERM EFFECTS OF SOLID ROCKET FUELS COMPONENT

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Abstract

The chronic oral toxicity and long-term effects of the basic lead-nickel salt of phthalic acid have been investigated by long-term oral ingestion of white outbred rats. The compound at doses of 1.0 mg/kg; 0.3 mg/kg and 0.1 mg/kg have changed the physiological, behavioral, hematological, biochemical, immunological parameters, as well as the relative weight of internal organs of animals in the six months experiments. The threshold of chronic oral toxicity of the substance is set at 0.1 mg / kg.

The study of long-term effects revealed the absence of its mutagenic activity both at the gene (Ames test) and chromosomal (dominant lethal method) levels. In addition, the analyzed compound did not adversely affect the reproductive function of male rats. When entering the body of females during gestation, the toxicant did not reveal embryo-lethal and teratogenic properties.

However, chronic administration of the compound into the body of non-pregnant animals at a dose of 1.0 mg/kg contributed to a significant decrease relative to the control of the mass and disk diameter of the placenta, which indirectly indicated the functional inferiority of the organ. Therefore, the considered level of the substance is defined as a threshold for gonadotoxic effect.

The obtained data are taken into account in developing of hygienic standard of the estimated component of solid rocket fuels in water reservoirs.

About the authors

A. A. Maslennikov

Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency

Author for correspondence.
Email: maslennikov@rihtop.ru

Maslennikov Aleksandr Aleksandrovich

400048, Volgograd

Russian Federation

V. A. Antonov

Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency

Email: antonov@rihtop.ru

Antonov Valery Alexeyevich

400048, Volgograd

Russian Federation

L. Yu. Bocharova

Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency

Email: fake@neicon.ru

Bocharova Lyudmila Yuryevna

400048, Volgograd

Russian Federation

L. P. Tochilkina

Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency

Email: tochilkina@rihtop.ru

Tochilkina Lyudmila Petrovna

400048, Volgograd

Russian Federation

O. N. Novikova

Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency

Email: novikova@rihtop.ru

Novikova Olga Nikolaevna

400048, Volgograd

Russian Federation

N. V. Khodykina

Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency

Email: hodykina@rihtop.ru

Khodykina Nina Vladimirovna

400048, Volgograd

Russian Federation

M. A. Grishina

Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency

Email: grishina@rihtop.ru

Grishina Marina Anatolievna

400048, Volgograd

Russian Federation

A. Ya. Pocheptsov

Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency

Email: pochepcov@rihtop.ru

Pocheptsov Alexander Yakovlevich

400048, Volgograd

Russian Federation

References

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Copyright (c) 2019 Maslennikov A.A., Antonov V.A., Bocharova L.Y., Tochilkina L.P., Novikova O.N., Khodykina N.V., Grishina M.A., Pocheptsov A.Y.


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