Email this article EXPERIMENTAL EVALUATION OF CHRONIC ORAL TOXICITY AND LONG-TERM EFFECTS OF SOLID ROCKET FUELS COMPONENT
- Authors: Maslennikov A.A.1, Antonov V.A.1, Bocharova L.Y.1, Tochilkina L.P.1, Novikova O.N.1, Khodykina N.V.1, Grishina M.A.1, Pocheptsov A.Y.1
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Affiliations:
- Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency
- Issue: No 1 (2019)
- Pages: 12-17
- Section: Articles
- Published: 28.02.2019
- URL: https://ruspoj.com/0869-7922/article/view/641128
- DOI: https://doi.org/10.36946/0869-7922-2019-1-12-17
- ID: 641128
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Abstract
The chronic oral toxicity and long-term effects of the basic lead-nickel salt of phthalic acid have been investigated by long-term oral ingestion of white outbred rats. The compound at doses of 1.0 mg/kg; 0.3 mg/kg and 0.1 mg/kg have changed the physiological, behavioral, hematological, biochemical, immunological parameters, as well as the relative weight of internal organs of animals in the six months experiments. The threshold of chronic oral toxicity of the substance is set at 0.1 mg / kg.
The study of long-term effects revealed the absence of its mutagenic activity both at the gene (Ames test) and chromosomal (dominant lethal method) levels. In addition, the analyzed compound did not adversely affect the reproductive function of male rats. When entering the body of females during gestation, the toxicant did not reveal embryo-lethal and teratogenic properties.
However, chronic administration of the compound into the body of non-pregnant animals at a dose of 1.0 mg/kg contributed to a significant decrease relative to the control of the mass and disk diameter of the placenta, which indirectly indicated the functional inferiority of the organ. Therefore, the considered level of the substance is defined as a threshold for gonadotoxic effect.
The obtained data are taken into account in developing of hygienic standard of the estimated component of solid rocket fuels in water reservoirs.
About the authors
A. A. Maslennikov
Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency
Author for correspondence.
Email: maslennikov@rihtop.ru
Maslennikov Aleksandr Aleksandrovich
400048, Volgograd
Russian FederationV. A. Antonov
Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency
Email: antonov@rihtop.ru
Antonov Valery Alexeyevich
400048, Volgograd
Russian FederationL. Yu. Bocharova
Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency
Email: fake@neicon.ru
Bocharova Lyudmila Yuryevna
400048, Volgograd
Russian FederationL. P. Tochilkina
Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency
Email: tochilkina@rihtop.ru
Tochilkina Lyudmila Petrovna
400048, Volgograd
Russian FederationO. N. Novikova
Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency
Email: novikova@rihtop.ru
Novikova Olga Nikolaevna
400048, Volgograd
Russian FederationN. V. Khodykina
Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency
Email: hodykina@rihtop.ru
Khodykina Nina Vladimirovna
400048, Volgograd
Russian FederationM. A. Grishina
Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency
Email: grishina@rihtop.ru
Grishina Marina Anatolievna
400048, Volgograd
Russian FederationA. Ya. Pocheptsov
Research Institute of Hygiene, Toxicology and Occupational Pathology of the Federal Medical and Biological Agency
Email: pochepcov@rihtop.ru
Pocheptsov Alexander Yakovlevich
400048, Volgograd
Russian FederationReferences
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