PECULIARITIES OF METABOLIC CHANGES IN EXPERIMENTAL ANIMALS AT EARLY TERMS OF PHARMACOLOGICAL CORRECTION OF TOXIC LIVER DISEASES

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Abstract

The paper presents the results of studies on metabolic changes in experimental animals with acute tetrachloromethane poisoning and further damage correction using substances possessing hepatoprotective properties: oxymethyluracil, ademethionine and ethylmethylhydroxypyridine succinate. It has been revealed that oxymethyluracil exhibits heteroprotective properties at the earliest stages of acute toxic liver damage with chemical toxicants: it has membrane-stabilizing properties, normalizes the levels of antioxidant system parameters, thereby restoring the oxidative-antioxidant balance in hepatocytes. Oxymethyluracil has more pronounced hepatoprotective properties at the early stages of treatment in comparison with ademethionine and ethylmethylhydroxypyridine succinate. The results obtained are important in terms of the prospective use of oxymethyluracil for the relief of hepatotoxic effects in acute exposure to hepatropic chemicals under environmental and industrial poisoning.

About the authors

G. V. Timasheva

Ufa Institute of Occupational Health and Human Ecology

Author for correspondence.
Email: gulnara-vt@yandex.ru
450106, Ufa Russian Federation

E. F. Repina

Ufa Institute of Occupational Health and Human Ecology

Email: e.f.repina@bk.ru
450106, Ufa Russian Federation

D. O. Karimov

Ufa Institute of Occupational Health and Human Ecology

Email: karimovdo@gmail.com
450106, Ufa Russian Federation

N. Yu. Khusnutdinova

Ufa Institute of Occupational Health and Human Ecology

Email: h-n-yu@yandex.ru
450106, Ufa Russian Federation

G. F. Mukhammadieva

Ufa Institute of Occupational Health and Human Ecology

Email: ufniimt@mail.ru
450106, Ufa Russian Federation

A. B. Bakirov

Ufa Institute of Occupational Health and Human Ecology

Email: ufniimt@mail.ru
450106, Ufa Russian Federation

D. A. Smolyankin

Ufa Institute of Occupational Health and Human Ecology

Email: Smolyankin.denis@yandex.ru
450106, Ufa Russian Federation

S. S. Baigildin

Ufa Institute of Occupational Health and Human Ecology

Email: baigildin.samat@yandex.ru
450106, Ufa Russian Federation

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Copyright (c) 2020 Timasheva G.V., Repina E.F., Karimov D.O., Khusnutdinova N.Y., Mukhammadieva G.F., Bakirov A.B., Smolyankin D.A., Baigildin S.S.


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