STATISTICAL ANALYSIS OF VERATRUM ACUTE POISONINGS DURING 2014-2018 IN MOSCOW, SAINT PETERSBURG, OMSK, CHITA, AND KHANTY-MANSIYSK AUTONOMOUS OKRUG – UGRA

Cover Page

Cite item

Full Text

Abstract

Acute hellebore poisoning is characteristic for the Russian Federation because of the use of this plant for the treatment of alcoholism at home. The varying severity of clinical symptoms, which sometimes become lifethreatening, the lack of anamnestic reliable information about the use of hellebore and the difficulties of chemical and toxicological confirmation of its use complicate the diagnosis of acute poisoning, and do not allow timely medical care. In addition, there is no classification of hellebore poisoning in ICD-10, block (T51-T65), which also affects the assessment of the actual frequency of this acute intoxication.
The purpose of this work is to clarify the number of acute hellebore poisoning in the Russian Federation. The analysis of medical records of patients hospitalized with acute hellebore poisoning in toxicological departments of a number of subjects of the Russian Federation for 2014 - 2018 was carried out. The dynamics of such acute poisoning over the specified period, the gender and age composition of victims, and the circumstances of poisoning were revealed. The relevance of developing methods of chemical and toxicological analysis for the determination of hellebore alkaloids is confirmed, which will increase the reliability of diagnosis and detection of cases of hellebore poisoning.

About the authors

E. V. Melnik

I.M. Sechenov First Moscow State Medical University

Author for correspondence.
Email: elizaveta-m05@mail.ru

Melnik Elizaveta Valer’evna

119991, Mosсow

Russian Federation

M. V. Belova

I.M. Sechenov First Moscow State Medical University; N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department

Email: maniabel@gmail.com

Belova Mariya Vladimirovna

119991, Mosсow

129090, Mosсow

Russian Federation

A. N. Lodyagin

Saint Petersburg Research Institute of Emergency Medicine n.a. I.I. Dzhanelidze

Email: alodyagin@mail.ru

Lodyagin Aleksey Nikolaevich

192242, Saint Petersburg

Russian Federation

A. V. Sabaev

Municipal Clinical Hospital of Emergency Medical Care №1 of Omsk

Email: alesabaev@yandex.ru

Sabaev Aleksandr Vladimirovich

644112, Omsk

Russian Federation

B. B. Yatsinyuk

Khanty-Mansiysk State Medical Academy

Email: tocsboris@mail.ru

Yatsinyuk Boris Borisovich

628011, Khanty-Mansiysk

Russian Federation

I. A. Afonkin

Municipal Clinical Hospital №1

Email: i.afonkin@yandex.ru

Afonkin Igor Anatol’evich

672039, Chita

Russian Federation

I. A. Tyurin

N.V. Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department

Email: gcms@mail.ru

Tyurin Igor Aleksandrovich

129090, Mosсow

Russian Federation

G. V. Ramenskaya

I.M. Sechenov First Moscow State Medical University

Email: ramenskaia@mail.ru

Ramenskaya Galina Vladislavovna

119991, Mosсow

Russian Federation

References

  1. Li H.-J., Jiang Y., Li P. Chemistry, bioactivity and geographical diversity of steroidal alkaloids from the Liliaceae family. Nat. Prod. Rep. 2006; 23(5): 735.
  2. Суворов А.В., Кауров Я.В., Суворов М.А. Особенности нарушения ритма и проводимости сердца при острых отравлениях кардиотоксическими веществами. Вестник Российского университета дружбы народов. Серия: Медицина. 2014; 3: 26-30. / Suvorov A.V., Kaurov Ya.V., Suvorov M.A. Violation of rhythm and conductivity of heart in acute poisoning with cardiotoxic substances. Bulletin of the Peoples’ Friendship University of Russia. Series: Medicine. 2014; 3: 26-30 (in Russian).
  3. Мишина Т.П., Лукьянова И.Ю., Бидерман Ф.М., Афанасьева И.В. Отравление чемерицей. Скорая медицинская помощь. 2013; 14(3): 48-51. / Mishina T.P., Lukyanova I.Yu., Biederman F.M., Afanaseva I.V. Hellebore poisoning. Emergency Medical Care. 2013; 14(3):48- 51 (in Russian).
  4. Schep L.J., Schmierer D.M., Fountain J.S. Veratrum poisoning. Toxicol. Rev. 2006; 25(2): 73-78.
  5. Зобнин Ю.В., Любимов Б.М., Малых А.Ф., Провадо И.П., Третьяков А.Б. Отравление алкалоидами вератрина по данным Иркутского токсикологического Центра. Сибирский медицинский журнал (Иркутск). 2006; 7: 91-93. Ссылка активна на 03.06.2020. Available at: https://cyberleninka.ru/article/n/otravleniealkaloidami-veratrina-po-dannymirkutskogo-toksikologicheskogo-tsentra. / Zobnin Yu.V., Lyubimov B.M., Malykh A.F., Provado I.P., Tretjakov A.B. Poisoning with alkaloids of veratrine according to the date of the Irkutsk Toxicological Center. Siberian Medical Journal (Irkutsk). 2006; 7: 91-93 (in Russian). Available at: https://cyberleninka.ru/article/n/otravleniealkaloidami-veratrina-po-dannymirkutskogo-toksikologicheskogo-tsentra (Accessed 3 June 2020).
  6. Лужников Е.А., ред. Медицинская токсикология: национальное руководство. М.: ГЭОТАР-Медиа; 2012. / Luzhnikov E.A. Medical toxicology: national guidelines. Moscow: GEOTAR-Media; 2012 (in Russian).
  7. Рожанец В.В., Нужный В.П. О допустимости использования чемерицы Лобеля (кукольник) для условно-рефлекторной терапии алкоголизма. Наркология. 2003; 2(4):45-48. / Rozhanets V.V., Nuzhny V.P. About permissibility of veratrum intake for conditioned reflex therapy of alcoholism. Narcology. 2003; 2(4): 45-48 (in Russian).
  8. Мусихин И.Г., Шугурова Г.Г., Шевченко Е.В. Отравление кукольником (чемерицей). Неотложная терапия. 2004; 1/2: 59-61. / Musikhin I.G., Shugurova G.G., Shevchenko E.V. Veratrum poisoning. Emergency therapy. 2004; 1/2: 59-61 (in Russian).
  9. Международная классификация болезней 10-го пересмотра (МКБ- 10). Ссылка активна на 03.06.2020. Available at: https://mkb-10.com/index. php?pid=19257. / The 10th revision of the International classification of diseases (ICD-10). The link is active on 03.06.2020. Available at: https://mkb-10.com/index.php?pid=19257 (Accessed 3 June 2020).
  10. А.В. Сабаев, В.Т. Долгих, А.Г. Коробейникова, С.И. Полубоярцев. Анализ причин и структуры острой химической травмы по данным Центра лечения острых отравлений города Омска за 2000—2004 годы. Общая реаниматология. 2006; 2 (2): 33-36. / Sabaev A.V., Dolgikh V.T., Korobejnikova A.G., Polubojarcev S.I. Analysis of the causes and pattern of acute chemical injury: the 2000-2004 data of the Omsk Acute Intoxication Center. General resuscitation science. 2006; 2 (2): 33-36 (in Russian).

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2020 Melnik E.V., Belova M.V., Lodyagin A.N., Sabaev A.V., Yatsinyuk B.B., Afonkin I.A., Tyurin I.A., Ramenskaya G.V.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 81728 от 11 декабря 2013.