МETHOD OF NON-INVASIVE DIAGNOSTICS OF POISONING BY SUBSTANCES OF NEUROPARALYTIC ACTION WITH THE USE OF A BIOSENSOR IN CLINICAL AND FIELD CONDITION

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Abstract

The questions of substantiation of the need to create and the prospects of developing a method for non-invasive diagnosis of lesions by compounds of neuroparalytic action in the field that meet modern requirements for sensitivity, specificity and speed are considered. As a result of the research, a method for early and reliable noninvasive diagnosis of lesions by neuroparalytic compounds in the field using an optical biosensor of irreversible cholinesterase inhibitors was proposed.

About the authors

Е. Т. Gainullina

27th Scientific Center of the Ministry of Defence of the Russian Federation

Author for correspondence.
Email: fake@neicon.ru

Gainullina Era Tazetdinovna

105005, Moscow

Russian Federation

S. В. Ryzhikov

Lomonocov Moscow State University, Faculty of Physics

Email: sbr@physics.msu.ru

Ryzhikov Sergey Borisovich

 119991, Moscow

 

Russian Federation

V. N. Fateenkov

27th Scientific Center of the Ministry of Defence of the Russian Federation

Email: fake@neicon.ru

Fateenkov Vladimir Nikolaevich

105005, Moscow

Russian Federation

М. A. Ponsov

27th Scientific Center of the Ministry of Defence of the Russian Federation

Email: fake@neicon.ru

Ponsov Mikhail Aleksandrovich

105005, Moscow

Russian Federation

L. V. Petrakova

27th Scientific Center of the Ministry of Defence of the Russian Federation

Email: fake@neicon.ru

Petrakova Lidiya Vasilievna

105005, Moscow

Russian Federation

References

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  2. Rodney Muhumuza. Non-invasive malaria test wins Africa engineering prize. Avaible at: https://medicalxpress.com/news/2018-06-non-invasive-malaria- Africa-prize.html. (Accessed 1 Jule 2020).
  3. Hall C.A., Chilcott R.P. Eyeing up the Future of the Pupillary Light Reflex in Neurodiagnostics. Diagnostics. 2018, 8(1): 19; doi. B:10.3390/ diagnostics8010019.
  4. Kori R.K., Jain A.K., Yadav R.S. Biomarkers: An Essential Gizmo in Pesticide Toxicity. Biomark J. 2016, 2:1. doi: 10.21767/2472-1646.100009.
  5. Gainullina E.T., Gulikova D.K., Korneev D.O., Oreshkin D.V., Ryzhikov S.B., Fateenkov V.N. Biosensors as tools of environmental monitoring for organophosphorus nerve agents. Journal of Analytical Chemistry. 2015; V. 70 (7): 771-780.
  6. Fourth Meeting of the Scientific Advisory Board Temporary Working Group on the Convergence of Chemistry and Biology. 5-7 November 2013. –Hague. – 2013.
  7. Gainullina E.T., Korneev D.O., Fateenkov V.N. Optical biosensor of irreversible cholinesterase inhibitors in the air. Patent RF, N 2654294; 2018 (in Russian).

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Copyright (c) 2021 Gainullina Е.Т., Ryzhikov S.В., Fateenkov V.N., Ponsov М.A., Petrakova L.V.


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