Email this article CORRECTION OF THE KIDNEYS STRUCTURE DISTURBANCES IN RATS WITH SUBLIMATE NEPHROPATHY USING A COMBINATION OF TAURIN WITH ZINC DIASPARTATE
- Authors: Basalai O.N.1, Mikhalchuk E.C.1, Bushma M.I.1, Zimatkin S.M.1
-
Affiliations:
- УО «Гродненский государственный медицинский университет» МЗ РБ
- Issue: No 2 (2015)
- Pages: 31-34
- Section: Articles
- Published: 06.04.2015
- URL: https://ruspoj.com/0869-7922/article/view/641310
- DOI: https://doi.org/10.15690/vramn446
- ID: 641310
Cite item
Full Text
Abstract
A combination of taurine (20g/mole, 2.5 g) with zinc diaspartate (1 g/mole, 0.35g) named “taucine”, administrated in the rat stomach at doses of 250 mg/kg and 500 mg/kg over 14 days has a dose-dependent nephro-protective action in rats with sublimate nephropathy ( intraabdominally 0.1 mg/kg over 14 days) . It manifests in an increased volume of the primary urine in cortical nephrons glomerales because of a weakened compression of their capsule by hydropic fluid, in reduction of the inner diameter of cortical nephrons proximal convoluted tubules as consequence of a less pronounced «inner tubular» hydronephrosis and increased height of lining epithelial cells. A detailed analysis of the latter shows that they are less damaged by sublimate: the percentage of undamaged cells increases because of decrease with destruction of apical sections and increase of cells height by ½ as well.
About the authors
Olga Nikolaevna Basalai
УО «Гродненский государственный медицинский университет» МЗ РБ
Author for correspondence.
Email: noemail@neicon.ru
Аспирант, ассистент кафедры фармакологии им. профессора М.В. Кораблева УО ГрГМУ, 230023, г. Гродно, Республика Беларусь
e-mail: Basalai2012@mail.ru
BelarusElena Cheslavovna Mikhalchuk
УО «Гродненский государственный медицинский университет» МЗ РБ
Email: noemail@neicon.ru
К. б. н., доцент кафедры гистологии, цитологии и эмбриологии УО ГрГМУ, 230023, г. Гродно, Республика Беларусь
e-mail: milena6519@mail.ru
BelarusMikhail Ivanovich Bushma
УО «Гродненский государственный медицинский университет» МЗ РБ
Email: noemail@neicon.ru
Д. м. н., профессор, зав. кафедры фармакологии им. профессора М.В. Кораблева УО ГрГМУ, 230023, г. Гродно, Республика Беларусь
e-mail: pharma@grsmu.by
BelarusSergey Mikhaylovich Zimatkin
УО «Гродненский государственный медицинский университет» МЗ РБ
Email: noemail@neicon.ru
Д. б. н., профессор, зав. кафедры гистологии, цитологии и эмбриологии УО ГрГМУ, 230023, г. Гродно, Республика Беларусь
e-mail: zimatkin@grsmu.by
BelarusReferences
- Lawrence H. L. [et al] Influence of exogenous thiols on inorganic mercury induced injury in renal proximal and distal tubular cells from normal and un inephrectomized rats. J. Pharmacol. Exp. 1999;5:492-02.
- Zalups R.K. Molecular interactions with mercury in the kidney. Pharmacological Reviews. 2000; 5: 113-44.
- Xiao Y. Effect of ischemia-reperfusion on the renal brush border membrane sodium dependent phosphate co transporter NaPi-2. Can. J. Physiol. and Pharmacol. 2001; 7: 206-12.
- Mozhejko L.A. Classical methods of coloring in histology. GrGMU. 2010; 1: 23-34 (in Russian).
- Rebrova O.Yu. Statistical analysis of medical data. Moskva: MediaSfera; 2002 (in Russian).
- aporozhan B.H., Gozhenko A.I., Ambrosychuk E.V. Features of osmoreguliruyushchy function of kidneys at anemia of pregnant women in the conditions of water-salt loadings. Nefrologya. 2002; 6:75-78 (in Russian).
- Harada H. [et al.] Oral ta urine supplementation prevents the development of ethanol-induced hypertension in rats. Hypertens Res. 2000;23: 277-284.
- Formigari A., Irato P., Santon A. Zinc, antioxidant systems and metallothionein in metal mediated-apoptosis: biochemical and cytochemical aspects. Comp. Biochem. Physiol. Pt. C. 2007; 146: 443-459.
- Truong-Tran A.Q. [et al.] The role of zinc in caspase activation and apoptotic cell death. Biometals. 2001; 14: 315-330.
Supplementary files
