CORRECTION OF THE KIDNEYS STRUCTURE DISTURBANCES IN RATS WITH SUBLIMATE NEPHROPATHY USING A COMBINATION OF TAURIN WITH ZINC DIASPARTATE

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Abstract

A combination of taurine (20g/mole, 2.5 g) with zinc diaspartate (1 g/mole, 0.35g) named “taucine”, administrated in the rat stomach at doses of 250 mg/kg and 500 mg/kg over 14 days has a dose-dependent nephro-protective action in rats with sublimate nephropathy ( intraabdominally 0.1 mg/kg over 14 days) . It manifests in an increased volume of the primary urine in cortical nephrons glomerales because of a weakened compression of their capsule by hydropic fluid, in reduction of the inner diameter of cortical nephrons proximal convoluted tubules as consequence of a less pronounced «inner tubular» hydronephrosis and increased height of lining epithelial cells. A detailed analysis of the latter shows that they are less damaged by sublimate: the percentage of undamaged cells increases because of decrease with destruction of apical sections and increase of cells height by ½ as well.

About the authors

Olga Nikolaevna Basalai

УО «Гродненский государственный медицинский университет» МЗ РБ

Author for correspondence.
Email: noemail@neicon.ru

Аспирант, ассистент кафедры фармакологии им. профессора М.В. Кораблева УО ГрГМУ, 230023, г. Гродно, Республика Беларусь

e-mail: Basalai2012@mail.ru

Belarus

Elena Cheslavovna Mikhalchuk

УО «Гродненский государственный медицинский университет» МЗ РБ

Email: noemail@neicon.ru

К. б. н., доцент кафедры гистологии, цитологии и эмбриологии УО ГрГМУ, 230023, г. Гродно, Республика Беларусь

e-mail: milena6519@mail.ru

Belarus

Mikhail Ivanovich Bushma

УО «Гродненский государственный медицинский университет» МЗ РБ

Email: noemail@neicon.ru

Д. м. н., профессор, зав. кафедры фармакологии им. профессора М.В. Кораблева УО ГрГМУ, 230023, г. Гродно, Республика Беларусь

e-mail: pharma@grsmu.by

Belarus

Sergey Mikhaylovich Zimatkin

УО «Гродненский государственный медицинский университет» МЗ РБ

Email: noemail@neicon.ru

Д. б. н., профессор, зав. кафедры гистологии, цитологии и эмбриологии УО ГрГМУ, 230023, г. Гродно, Республика Беларусь

e-mail: zimatkin@grsmu.by

Belarus

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Copyright (c) 2015 Basalai O.N., Mikhalchuk E.C., Bushma M.I., Zimatkin S.M.


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