CORRECTION BY TAUCIN OF LIVER METABOLIС AND FUNCTIONAL LIVER DISTURBANCES IN RATS INROXICATED WITH PARACETAMOL

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Abstract

The combination of taurine (50 g/mole, 6.25g) with zinc diaspartate (1 g/mole, 0.35g) named «taucine-50», administrated in the rat stomach (0.50 g/kg over 10 days )increases the paracetamol-inhibited (administrated in the stomach 2.50 g/kg over 5 days) activity of succinate dehydrogenase, lactate dehydrogenase (LDH), nicotinamine adenine nucleotide – dehydrogenase (NADH) and acidic phosphatase (ACPH) in the rat liver and decreases in plasma an increased activity of alanine aminotransferase (ALT), aspartate aminotransferase (AspAT) and alkaline phosphatase (ALP) as well as elevated content of total bilirubin, its conjugated forms and cholesterol. Hepatoprotective effect of «taucin-20» (0.5 g/kg/day) is less pronounced.

About the authors

Anastasiya Urjevna Pashko

Education Institution "Grodno State Medical University" of Ministry of Health, Republic of Belarus: M.V. Korablev Pharmacology Department

Author for correspondence.
Email: anfstas@inbox.ru

Ассистент и аспирант кафедры фармакологии им. профессора М.В. Кораблева УО «Гродненский государственный медицинский университет» МЗ Республики Беларусь, 230005, г. Гродно, Республика Беларусь,

e-mail: anfstas@inbox.ru

Belarus

Olga Alexandrovna Borisenok

Education Institution "Grodno State Medical University" of Ministry of Health, Republic of Belarus: M.V. Korablev Pharmacology Department

Email: noemail@neicon.ru

Ассистент кафедры фармакологии им. профессора М.В. Кораблева УО «Гродненский государственный медицинский университет» МЗ Республики Беларусь, 230005, г. Гродно, Республика Беларусь 

Belarus

Mihail Ivanovich Bushma

Education Institution "Grodno State Medical University" of Ministry of Health, Republic of Belarus: M.V. Korablev Pharmacology Department

Email: pharma@grsmu.by

Д.м.н., профессор кафедры фармакологии им. профессора М.В. Кораблева УО «Гродненский государственный медицинский университет» МЗ Республики Беларусь, 230005, г. Гродно, Республика Беларусь,

e-mail: pharma@grsmu.by

Belarus

References

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  8. But-Gusaim L.St., Gerashchenko N.V., Bloshko T.E. Prospects of use of preparations of zinc in a perinatologi. Materialy nauchnoprakticheskoy konferentsii posvyashchennoy 60 let sluzhbe skoroy pomoshchi i 10 let UZ «GKO SMP». 5-7 sentyabrya 2005. Grodno: GrGMU; 2005 (in Russian).

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