Email this article NEPHROPROTECTIVE ACTION OF COMBINATION OF TAURINE WITH ZINC DIASPARTATE IN RATS WITH GENTAMICIN NEPHROPATHY
- Authors: Basalai O.N.1, Mikhalchuk E.C.1, Zimatkin S.M.1, Bushma M.I.1, Borisenok O.A.1
-
Affiliations:
- Education establishment «Grodno State Medical University» of Ministry of health of Republic of Belarus: M.V. Korablev
- Issue: No 5 (2015)
- Pages: 21-24
- Section: Articles
- Published: 01.10.2015
- URL: https://ruspoj.com/0869-7922/article/view/641338
- DOI: https://doi.org/10.15690/vramn510
- ID: 641338
Cite item
Full Text
Abstract
In rats with gentamicin nephropathy (gentamicin injected intra-abdominally, 60 mg/kg daily over 10 days), a combination of taurine with zinc diaspartate administrated in the stomach in the ratio of 1.0 g + 0.14g -250 mg/kg and particularly of 1.0+0.06 g - 500 mg/ kg ) has a nephroprotective effect that is proved by weakened lesions of cortical nephrons proximal convoluted tubules.
About the authors
Olga Nikolaevna Basalai
Education establishment «Grodno State Medical University» of Ministry of health of Republic of Belarus: M.V. Korablev
Author for correspondence.
Email: noemail@neicon.ru
Аспирант кафедры фармакологии им. проф. М.В. Кораблева УО ГрГМУ, 230023, г. Гродно, Беларусь
e-mail: basalai2012@mail.ru
Russian FederationElena Cheslavovna Mikhalchuk
Education establishment «Grodno State Medical University» of Ministry of health of Republic of Belarus: M.V. Korablev
Email: noemail@neicon.ru
К.б.н., доцент каф. гистологии, цитологии и эмбриологии УО ГрГМУ, 230023, г. Гродно, Беларусь
e-mail: milena6519@mail.ru
Russian FederationSergey Mikhaylovich Zimatkin
Education establishment «Grodno State Medical University» of Ministry of health of Republic of Belarus: M.V. Korablev
Email: noemail@neicon.ru
Д.б.н., профессор, зав. каф. гистологии, цитологии и эмбриологии УО ГрГМУ, 230023, г. Гродно, Беларусь
e-mail: zimatkin@grsmu.by
Russian FederationMikhail Ivanovich Bushma
Education establishment «Grodno State Medical University» of Ministry of health of Republic of Belarus: M.V. Korablev
Email: noemail@neicon.ru
Д.м.н., профессор кафедры фармакологии им. профессора М.В. Кораблева УО ГрГМУ, 230023, г. Гродно, Беларусь
e-mail: pharma@grsmu.by
Russian FederationOlga Aleksandrovna Borisenok
Education establishment «Grodno State Medical University» of Ministry of health of Republic of Belarus: M.V. Korablev
Email: noemail@neicon.ru
К.м.н., ст. преподаватель кафедры фармакологии им. профессора М.В. Кораблева УО ГрГМУ, 230023, г. Гродно, Беларусь
pharma@grsmu.by
Russian FederationReferences
- Strachunskiy L.S. Modern antimicrobic chemotherapy. Moskva: Borges; 2002 (in Russian).
- Basalay O.N., Mikhal’chuk E.Ch., Zimatkin S.M., Bushma M.I. Correction combination of taurine and zinc diaspartatom metabolic disorder in the kidney and organ function in rats with gentamicin nephropathy. Toksikologicheskiy vestnik. 2014; 127 (4): 25-29 (in Russian).
- W. Maret. Molecular aspects of human cellular zinc homeostasis: redox control of zinc potentials and zinc signals. Biometals. 2009; 22: 149157.
- Mozheyko L.A. Classical staining methods in histology. Grodno: GrGMU; 2010 (in Russian).
- Rebrova O.Yu. Statistical analysis of medical data. Application software package STATISTICA. Moskva: MediaSfera; 2002 (in Russian).
- Beauchamp D. et al. Attenuation of gentamicin induced nephrotoxicity in rats by fleroxacin. Antimicrob. Agents Chemother. 1997; 41: 1237-1245.
- Houghton D.C. et al. A light and electron microscopic analysis of gentamicin nephrotoxicity in rats. Am. J. Pathol. 1976; 82: 589-12.
- Bykov V. L. Private Histology (brief survey course), 2nd ed. SPb: SOTIS; 1997 (in Russian).
- Sheybak V.M., Sheybak L.N. The biological role of taurine in mammals. Meditsinskie novosti. 2005; 10: 65-15 (in Russian).
- Sheybak V. M., Sheybak L. N. Biosynthesis and exchange of taurine. Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta. 2005; 1: 9-12 (in Russian).
- Sheybak V. M., Sheybak L. N. The biological role of zinc and zinc prospects for medical use-containing preparations. Grodno: GrGMU; 2003 (in Russian).
Supplementary files
