NEPHROPROTECTIVE ACTION OF COMBINATION OF TAURINE WITH ZINC DIASPARTATE IN RATS WITH GENTAMICIN NEPHROPATHY

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Abstract

In rats with gentamicin nephropathy (gentamicin injected intra-abdominally, 60 mg/kg daily over 10 days), a combination of taurine with zinc diaspartate administrated in the stomach in the ratio of 1.0 g + 0.14g -250 mg/kg and particularly of 1.0+0.06 g - 500 mg/ kg ) has a nephroprotective effect that is proved by weakened lesions of cortical nephrons proximal convoluted tubules.

About the authors

Olga Nikolaevna Basalai

Education establishment «Grodno State Medical University» of Ministry of health of Republic of Belarus: M.V. Korablev

Author for correspondence.
Email: noemail@neicon.ru

Аспирант кафедры фармакологии им. проф. М.В. Кораблева УО ГрГМУ, 230023, г. Гродно, Беларусь

e-mail: basalai2012@mail.ru

Russian Federation

Elena Cheslavovna Mikhalchuk

Education establishment «Grodno State Medical University» of Ministry of health of Republic of Belarus: M.V. Korablev

Email: noemail@neicon.ru

К.б.н., доцент каф. гистологии, цитологии и эмбриологии УО ГрГМУ, 230023, г. Гродно, Беларусь

e-mail: milena6519@mail.ru

Russian Federation

Sergey Mikhaylovich Zimatkin

Education establishment «Grodno State Medical University» of Ministry of health of Republic of Belarus: M.V. Korablev

Email: noemail@neicon.ru

Д.б.н., профессор, зав. каф. гистологии, цитологии и эмбриологии УО ГрГМУ, 230023, г. Гродно, Беларусь

e-mail: zimatkin@grsmu.by

Russian Federation

Mikhail Ivanovich Bushma

Education establishment «Grodno State Medical University» of Ministry of health of Republic of Belarus: M.V. Korablev

Email: noemail@neicon.ru

Д.м.н., профессор кафедры фармакологии им. профессора М.В. Кораблева УО ГрГМУ, 230023, г. Гродно, Беларусь

e-mail: pharma@grsmu.by

Russian Federation

Olga Aleksandrovna Borisenok

Education establishment «Grodno State Medical University» of Ministry of health of Republic of Belarus: M.V. Korablev

Email: noemail@neicon.ru

К.м.н., ст. преподаватель кафедры фармакологии им. профессора М.В. Кораблева УО ГрГМУ, 230023, г. Гродно, Беларусь

pharma@grsmu.by

Russian Federation

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  10. Sheybak V. M., Sheybak L. N. Biosynthesis and exchange of taurine. Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta. 2005; 1: 9-12 (in Russian).
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Copyright (c) 2015 Basalai O.N., Mikhalchuk E.C., Zimatkin S.M., Bushma M.I., Borisenok O.A.


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