Email this article On the issue of nongenotoxic cancerogenes
- Authors: Revazova Y.A.1, Ilyushina N.A.1
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Affiliations:
- Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F.F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
- Issue: No 4 (2021)
- Pages: 51-55
- Section: Discussion
- Published: 03.09.2021
- URL: https://ruspoj.com/0869-7922/article/view/641346
- DOI: https://doi.org/10.36946/0869-7922-2021-29-4-51-55
- ID: 641346
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Abstract
Introduction. Chemical, physical or biological factors that can cause the formation and expansion of cancer cells are diverse in terms of both activity and mechanisms of action, which leads to the complexity of assessing the risk of developing malignant neoplasms.
The aim. Discussion of the carcinogene classification based on their ability to interact with cell DNA and possible mechanisms of genetic control of carcinogenesis processes induced by non-genotoxic carcinogens.
The article draws attention to some controversial points related to the attribution of factors affecting an organism to genotoxic or non-genotoxic carcinogens. The terminology used in the literature to describe genotoxic (mutagenic) and carcinogenic factors is presented. The mechanisms of action of non-genotoxic carcinogens are discussed. The important role of experts determining the hazard to public health of factors with potential genotoxicity and carcinogenicity is noted.
Conclusion. Non-genotoxic carcinogens are capable of inducing malignant growth through mechanisms not associated with direct damage to genetic structures in the cell. However, the realization of carcinogenic effects caused by such factors is determined by various mechanisms of genetic control.
About the authors
Yulia A. Revazova
Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F.F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Author for correspondence.
Email: noemail@neicon.ru
ORCID iD: 0000-0001-5067-5469
Scopus Author ID: 6602245454
Russian FederationNataliya A. Ilyushina
Federal Budgetary Establishment of Science “Federal Scientific Center of Hygiene named after F.F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing
Email: iliushinana@fferisman.ru
ORCID iD: 0000-0001-9122-9465
Doctor of Biological Science, Head of the department of genetic toxicology, FBES “Federal Scientific Center of Hygiene named after F.F. Erisman” of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, 141014, Mytishchi, Moscow region, Russian Federation.
e-mail: iliushinana@fferisman.ru
Scopus Author ID: 6603049459
Russian FederationReferences
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